9α,11β-PGF2 and its stereoisomer PGF 2α are novel agonists of the chemoattractant receptor, CRTH2

Hilary Sandig; David Andrew; Ashley A. Barnes; Ian Sabroe; James Pease

doi:10.1016/j.febslet.2005.11.052

9α,11β-PGF2 and its stereoisomer PGF 2α are novel agonists of the chemoattractant receptor, CRTH2

Hilary Sandig, David Andrew, Ashley A. Barnes, Ian Sabroe, James Pease

Research output: Contribution to journal › Article › peer-review

Abstract

CRTH2 is a recently described chemoattractant receptor for the prostaglandin, PGD2, expressed by Th2 cells, eosinophils and basophils, and believed to play a role in allergic inflammation. Here we describe the potency of several PGD2 metabolites at the receptor to induce cell migration and activation. We report for the first time that the PGD2 metabolite, 9α,11β-PGF2, and its stereoisomer, PGF2α, are CRTH2 agonists. 9α,11β- PGF2 is a major metabolite produced in vivo following allergen challenge, whilst PGF2α is generated independently of PGD synthetase, with implications for CRTH2 signalling in the presence or absence of PGD2 production. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	373-379
Number of pages	6
Journal	FEBS Letters
Volume	580
Issue number	2
DOIs	https://doi.org/10.1016/j.febslet.2005.11.052
Publication status	Published - 23 Jan 2006

Keywords

Chemoattractant
CRTH2
Eosinophil
Inflammation
Prostaglandin

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10.1016/j.febslet.2005.11.052

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title = "9α,11β-PGF2 and its stereoisomer PGF 2α are novel agonists of the chemoattractant receptor, CRTH2",

abstract = "CRTH2 is a recently described chemoattractant receptor for the prostaglandin, PGD2, expressed by Th2 cells, eosinophils and basophils, and believed to play a role in allergic inflammation. Here we describe the potency of several PGD2 metabolites at the receptor to induce cell migration and activation. We report for the first time that the PGD2 metabolite, 9α,11β-PGF2, and its stereoisomer, PGF2α, are CRTH2 agonists. 9α,11β- PGF2 is a major metabolite produced in vivo following allergen challenge, whilst PGF2α is generated independently of PGD synthetase, with implications for CRTH2 signalling in the presence or absence of PGD2 production. {\textcopyright} 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",

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author = "Hilary Sandig and David Andrew and Barnes, {Ashley A.} and Ian Sabroe and James Pease",

year = "2006",

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language = "English",

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pages = "373--379",

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TY - JOUR

T1 - 9α,11β-PGF2 and its stereoisomer PGF 2α are novel agonists of the chemoattractant receptor, CRTH2

AU - Sandig, Hilary

AU - Andrew, David

AU - Barnes, Ashley A.

AU - Sabroe, Ian

AU - Pease, James

PY - 2006/1/23

Y1 - 2006/1/23

N2 - CRTH2 is a recently described chemoattractant receptor for the prostaglandin, PGD2, expressed by Th2 cells, eosinophils and basophils, and believed to play a role in allergic inflammation. Here we describe the potency of several PGD2 metabolites at the receptor to induce cell migration and activation. We report for the first time that the PGD2 metabolite, 9α,11β-PGF2, and its stereoisomer, PGF2α, are CRTH2 agonists. 9α,11β- PGF2 is a major metabolite produced in vivo following allergen challenge, whilst PGF2α is generated independently of PGD synthetase, with implications for CRTH2 signalling in the presence or absence of PGD2 production. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

AB - CRTH2 is a recently described chemoattractant receptor for the prostaglandin, PGD2, expressed by Th2 cells, eosinophils and basophils, and believed to play a role in allergic inflammation. Here we describe the potency of several PGD2 metabolites at the receptor to induce cell migration and activation. We report for the first time that the PGD2 metabolite, 9α,11β-PGF2, and its stereoisomer, PGF2α, are CRTH2 agonists. 9α,11β- PGF2 is a major metabolite produced in vivo following allergen challenge, whilst PGF2α is generated independently of PGD synthetase, with implications for CRTH2 signalling in the presence or absence of PGD2 production. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

KW - Chemoattractant

KW - CRTH2

KW - Eosinophil

KW - Inflammation

KW - Prostaglandin

U2 - 10.1016/j.febslet.2005.11.052

DO - 10.1016/j.febslet.2005.11.052

M3 - Article

C2 - 16378605

VL - 580

SP - 373

EP - 379

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

9α,11β-PGF2 and its stereoisomer PGF 2α are novel agonists of the chemoattractant receptor, CRTH2

Abstract

Keywords

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