A [13]rotaxane assembled via a palladium molecular capsule

Jesus Ferrando Soria, Antonio Fernandez Mato, Deepak Asthana, Selina Nawaz, Inigo Vitorica-Yrezabal, George Whitehead, Christopher Muryn, Floriana Tuna, Grigore Timco, Neil Burton, Richard Winpenny

    Research output: Contribution to journalArticlepeer-review


    Molecules that are the size of small proteins are difficult to make. The most frequently examined route is via self-assembly, and one particular approach involves molecular nanocapsules, where ligands are designed that will enforce the formation of specific polyhedra of metals within the core of the structure. Here we show that this approach can be combined with mechanically interlocking molecules to produce nanocapsules that are decorated on their exterior. This could be a general route to very large molecules, and is exemplified here by the synthesis and structural characterization of a [13]rotaxane, containing 150 metal centres. Small angle X-ray scattering combined with atomistic molecular dynamics simulations demonstrate the compound is intact in solution.
    Original languageEnglish
    Article number3720
    JournalNature Communications
    Publication statusPublished - 16 Aug 2019


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