A [13]rotaxane assembled via a palladium molecular capsule

Jesus Ferrando Soria; Antonio Fernandez Mato; Deepak Asthana; Selina Nawaz; Inigo Vitorica-Yrezabal; George Whitehead; Christopher Muryn; Floriana Tuna; Grigore Timco; Neil Burton; Richard Winpenny

doi:10.1038/s41467-019-11635-6

A [13]rotaxane assembled via a palladium molecular capsule

Jesus Ferrando Soria, Antonio Fernandez Mato, Deepak Asthana, Selina Nawaz, Inigo Vitorica-Yrezabal, George Whitehead, Christopher Muryn, Floriana Tuna, Grigore Timco, Neil Burton, Richard Winpenny

Research output: Contribution to journal › Article › peer-review

Abstract

Molecules that are the size of small proteins are difficult to make. The most frequently examined route is via self-assembly, and one particular approach involves molecular nanocapsules, where ligands are designed that will enforce the formation of specific polyhedra of metals within the core of the structure. Here we show that this approach can be combined with mechanically interlocking molecules to produce nanocapsules that are decorated on their exterior. This could be a general route to very large molecules, and is exemplified here by the synthesis and structural characterization of a [13]rotaxane, containing 150 metal centres. Small angle X-ray scattering combined with atomistic molecular dynamics simulations demonstrate the compound is intact in solution.

Original language	English
Article number	3720
Journal	Nature Communications
Volume	10
DOIs	https://doi.org/10.1038/s41467-019-11635-6
Publication status	Published - 16 Aug 2019

Access to Document

10.1038/s41467-019-11635-6Licence: CC BY

EPSRC National Research Facility for Electron Paramagnetic Resonance
Collison, D. (Academic lead), Mcinnes, E. (Academic lead), Tuna, F. (Academic lead), Bowen, A. (Academic lead), Shanmugam, M. (Senior Technical Specialist), Brookfield, A. (Technical Specialist), Fleming, E. (Other) & Cliff, M. (Platform Lead)
FSE Research
Facility/equipment: Facility

Cite this

@article{2624b0993f0a4fe68bbe8236d11b7477,

title = "A [13]rotaxane assembled via a palladium molecular capsule",

abstract = "Molecules that are the size of small proteins are difficult to make. The most frequently examined route is via self-assembly, and one particular approach involves molecular nanocapsules, where ligands are designed that will enforce the formation of specific polyhedra of metals within the core of the structure. Here we show that this approach can be combined with mechanically interlocking molecules to produce nanocapsules that are decorated on their exterior. This could be a general route to very large molecules, and is exemplified here by the synthesis and structural characterization of a [13]rotaxane, containing 150 metal centres. Small angle X-ray scattering combined with atomistic molecular dynamics simulations demonstrate the compound is intact in solution.",

author = "{Ferrando Soria}, Jesus and {Fernandez Mato}, Antonio and Deepak Asthana and Selina Nawaz and Inigo Vitorica-Yrezabal and George Whitehead and Christopher Muryn and Floriana Tuna and Grigore Timco and Neil Burton and Richard Winpenny",

year = "2019",

month = aug,

day = "16",

doi = "10.1038/s41467-019-11635-6",

language = "English",

volume = "10",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

TY - JOUR

T1 - A [13]rotaxane assembled via a palladium molecular capsule

AU - Ferrando Soria, Jesus

AU - Fernandez Mato, Antonio

AU - Asthana, Deepak

AU - Nawaz, Selina

AU - Vitorica-Yrezabal, Inigo

AU - Whitehead, George

AU - Muryn, Christopher

AU - Tuna, Floriana

AU - Timco, Grigore

AU - Burton, Neil

AU - Winpenny, Richard

PY - 2019/8/16

Y1 - 2019/8/16

N2 - Molecules that are the size of small proteins are difficult to make. The most frequently examined route is via self-assembly, and one particular approach involves molecular nanocapsules, where ligands are designed that will enforce the formation of specific polyhedra of metals within the core of the structure. Here we show that this approach can be combined with mechanically interlocking molecules to produce nanocapsules that are decorated on their exterior. This could be a general route to very large molecules, and is exemplified here by the synthesis and structural characterization of a [13]rotaxane, containing 150 metal centres. Small angle X-ray scattering combined with atomistic molecular dynamics simulations demonstrate the compound is intact in solution.

AB - Molecules that are the size of small proteins are difficult to make. The most frequently examined route is via self-assembly, and one particular approach involves molecular nanocapsules, where ligands are designed that will enforce the formation of specific polyhedra of metals within the core of the structure. Here we show that this approach can be combined with mechanically interlocking molecules to produce nanocapsules that are decorated on their exterior. This could be a general route to very large molecules, and is exemplified here by the synthesis and structural characterization of a [13]rotaxane, containing 150 metal centres. Small angle X-ray scattering combined with atomistic molecular dynamics simulations demonstrate the compound is intact in solution.

U2 - 10.1038/s41467-019-11635-6

DO - 10.1038/s41467-019-11635-6

M3 - Article

SN - 2041-1723

VL - 10

JO - Nature Communications

JF - Nature Communications

M1 - 3720

ER -

A [13]rotaxane assembled via a palladium molecular capsule

Abstract

Access to Document

Fingerprint

Equipment

EPSRC National Research Facility for Electron Paramagnetic Resonance

Cite this