A [ 17F]-fluoromethane PET/TMS study of effective connectivity

Todd Barnhart; Fabio Ferrarelli; H. Magnus Haraldsson; Todd E. Barnhart; Andy D. Roberts; Terrence R. Oakes; Marcello Massimini; Charles K. Stone; Ned H. Kalin; Giulio Tononi

A [ 17F]-fluoromethane PET/TMS study of effective connectivity

Todd Barnhart, Fabio Ferrarelli, H. Magnus Haraldsson, Todd E. Barnhart, Andy D. Roberts, Terrence R. Oakes, Marcello Massimini, Charles K. Stone, Ned H. Kalin, Giulio Tononi

Research output: Contribution to journal › Article › peer-review

Abstract

We used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [ 17F]- [CH 3F] ([ 17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [ 15O]-H 2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits. © 2004 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	103-113
Number of pages	10
Journal	Brain Research Bulletin
Volume	64
Issue number	2
Publication status	Published - 30 Aug 2004

Keywords

Effective connectivity
Fluoromethane
Functional neuroimaging
Positron emission tomography
Transcranial magnetic stimulation

Cite this

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title = "A [ 17F]-fluoromethane PET/TMS study of effective connectivity",

abstract = "We used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [ 17F]- [CH 3F] ([ 17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [ 15O]-H 2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits. {\textcopyright} 2004 Elsevier Inc. All rights reserved.",

keywords = "Effective connectivity, Fluoromethane, Functional neuroimaging, Positron emission tomography, Transcranial magnetic stimulation",

author = "Todd Barnhart and Fabio Ferrarelli and Haraldsson, {H. Magnus} and Barnhart, {Todd E.} and Roberts, {Andy D.} and Oakes, {Terrence R.} and Marcello Massimini and Stone, {Charles K.} and Kalin, {Ned H.} and Giulio Tononi",

year = "2004",

month = aug,

day = "30",

language = "English",

volume = "64",

pages = "103--113",

journal = "Brain Research Bulletin",

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TY - JOUR

T1 - A [ 17F]-fluoromethane PET/TMS study of effective connectivity

AU - Barnhart, Todd

AU - Ferrarelli, Fabio

AU - Haraldsson, H. Magnus

AU - Barnhart, Todd E.

AU - Roberts, Andy D.

AU - Oakes, Terrence R.

AU - Massimini, Marcello

AU - Stone, Charles K.

AU - Kalin, Ned H.

AU - Tononi, Giulio

PY - 2004/8/30

Y1 - 2004/8/30

N2 - We used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [ 17F]- [CH 3F] ([ 17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [ 15O]-H 2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits. © 2004 Elsevier Inc. All rights reserved.

AB - We used transcranial magnetic stimulation (TMS) in combination with positron emission tomography (PET) to investigate the effective connectivity of four cortical regions within the same study. By employing [ 17F]- [CH 3F] ([ 17F]-fluoromethane) as a radiotracer of blood-flow, we were able to obtain increased sensitivity compared to [ 15O]-H 2O for both cortical and subcortical structures. The brain areas investigated were left primary motor cortex, right primary visual cortex, and left and right prefrontal areas. We found that each site of stimulation yielded a different pattern of activation/deactivation consistent with its anatomical connectivity. Moreover, we found that TMS of prefrontal and motor cortical areas gave rise to trans-synaptic activation of subcortical circuits. © 2004 Elsevier Inc. All rights reserved.

KW - Effective connectivity

KW - Fluoromethane

KW - Functional neuroimaging

KW - Positron emission tomography

KW - Transcranial magnetic stimulation

M3 - Article

SN - 0361-9230

VL - 64

SP - 103

EP - 113

JO - Brain Research Bulletin

JF - Brain Research Bulletin

IS - 2

ER -

A [ 17F]-fluoromethane PET/TMS study of effective connectivity

Abstract

Keywords

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