A brief transdiagnostic group (the Take Control Course) compared to individual low-intensity CBT for depression and anxiety: a randomized non-inferiority trial

Lydia Morris, Karina Lovell, Philip Mcevoy, Richard Emsley, Lesley-Anne Carter, Dawn Edge, Rachel Bates, Tanya Wallwork, Warren Mansell

Research output: Contribution to journalArticlepeer-review

Abstract

Few studies have examined brief transdiagnostic groups. The Take Control Course (TCC) was developed for patients with common mental health problems in low-intensity Improving Access to Psychological Therapies (IAPT) services in the UK.
We examined whether TCC is non-inferior to individual low-intensity cognitive behaviour therapy (CBT) in a single-blind individually randomized parallel non-inferiority trial comparing TCC to individual low-intensity CBT. Primary outcomes were depression (PHQ9) and anxiety (GAD7) at 6-month follow-up (primary outcome point) and 12-month follow-up. The non-inferiority margin that we set, based on previous trials, corresponds to approximately 4 points on the PHQ9 and approximately 3.5 points on the GAD7.
Intention-to-treat (ITT) and per-protocol (PP) analyses of 6-month data of 156 randomised patients indicated that TCC was non-inferior to individual low-intensity CBT on anxiety (ITT Coefficient = 0.24; 95% CI: -1.45 to 1.92; d = 0.04; p = .79), and depression (ITT Coefficient = 0.82; 95% CI: -1.06 to 2.69; d = 0.14; p = .39) outcomes, and functioning (ITT Coefficient = 0.69; 95% CI: -2.56 to 3.94; d = 0.08; p = .68). The findings at 12 months were inconclusive and need further testing.
This randomised trial provides preliminary support TCC is not less effective than short-term individual CBT within IAPT.
Original languageEnglish
JournalCognitive Behaviour Therapy
Publication statusAccepted/In press - 28 Oct 2022

Keywords

  • transdiagnostic
  • group therapy
  • brief CBT
  • primary care
  • anxiety
  • depression

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