A capacitively coupled conductivity detector for electroseparations

Bernard Treves Brown; Danut Lonel Vaireanu; Peter R. Fielden; Bernard J Treves Brown

doi:10.1088/0957-0233/11/3/311

A capacitively coupled conductivity detector for electroseparations

Bernard Treves Brown, Danut Lonel Vaireanu, Peter R. Fielden, Bernard J Treves Brown

Research output: Contribution to journal › Article › peer-review

Abstract

A conductivity detector providing high-voltage isolation for electroseparations is described. It is based on an oscillator which is capacitively coupled to the measurement electrodes; the conductance between the electrodes determines the output frequency. The detector was evaluated using a small-volume (500 nl) conductivity cell (cell constant 5.1 × 10 3 m -1) which is described. It was then characterized using a factorial method and optimized to maximize the sensitivity (absolute change in frequency) to changes in conductivity. A novel method was used to determine the cell constant for a pair of microband electrodes (100 μm across on 200 μm centres) with electrolyte confined in a fine channel above them - this was 2615 ± 86 m -1 and the detector has been used with this cell for isotachophoretic separations reported elsewhere.

Original language	English
Pages (from-to)	244-251
Number of pages	7
Journal	Measurement Science and Technology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1088/0957-0233/11/3/311
Publication status	Published - Mar 2000

Keywords

Cell constant
CMOS oscillator
Conductivity
Detector
Electrode array
Electroseparations
Factorial design
Isotachophoresis
Microband electrodes
Simplex optimization

Access to Document

10.1088/0957-0233/11/3/311

Cite this

@article{1ad893c6067949858e3c15918db806a3,

title = "A capacitively coupled conductivity detector for electroseparations",

abstract = "A conductivity detector providing high-voltage isolation for electroseparations is described. It is based on an oscillator which is capacitively coupled to the measurement electrodes; the conductance between the electrodes determines the output frequency. The detector was evaluated using a small-volume (500 nl) conductivity cell (cell constant 5.1 × 10 3 m -1) which is described. It was then characterized using a factorial method and optimized to maximize the sensitivity (absolute change in frequency) to changes in conductivity. A novel method was used to determine the cell constant for a pair of microband electrodes (100 μm across on 200 μm centres) with electrolyte confined in a fine channel above them - this was 2615 ± 86 m -1 and the detector has been used with this cell for isotachophoretic separations reported elsewhere.",

keywords = "Cell constant, CMOS oscillator, Conductivity, Detector, Electrode array, Electroseparations, Factorial design, Isotachophoresis, Microband electrodes, Simplex optimization",

author = "{Treves Brown}, Bernard and Vaireanu, {Danut Lonel} and Fielden, {Peter R.} and Brown, {Bernard J Treves}",

note = "Department of Instrumentation and Analytical Science,University of Manchester Institute of Science and Technology,Manchester,UK. Journal",

year = "2000",

month = mar,

doi = "10.1088/0957-0233/11/3/311",

language = "English",

volume = "11",

pages = "244--251",

journal = "Measurement Science and Technology",

issn = "0957-0233",

publisher = "IOP Publishing Ltd",

number = "3",

}

TY - JOUR

T1 - A capacitively coupled conductivity detector for electroseparations

AU - Treves Brown, Bernard

AU - Vaireanu, Danut Lonel

AU - Fielden, Peter R.

AU - Brown, Bernard J Treves

N1 - Department of Instrumentation and Analytical Science,University of Manchester Institute of Science and Technology,Manchester,UK. Journal

PY - 2000/3

Y1 - 2000/3

N2 - A conductivity detector providing high-voltage isolation for electroseparations is described. It is based on an oscillator which is capacitively coupled to the measurement electrodes; the conductance between the electrodes determines the output frequency. The detector was evaluated using a small-volume (500 nl) conductivity cell (cell constant 5.1 × 10 3 m -1) which is described. It was then characterized using a factorial method and optimized to maximize the sensitivity (absolute change in frequency) to changes in conductivity. A novel method was used to determine the cell constant for a pair of microband electrodes (100 μm across on 200 μm centres) with electrolyte confined in a fine channel above them - this was 2615 ± 86 m -1 and the detector has been used with this cell for isotachophoretic separations reported elsewhere.

AB - A conductivity detector providing high-voltage isolation for electroseparations is described. It is based on an oscillator which is capacitively coupled to the measurement electrodes; the conductance between the electrodes determines the output frequency. The detector was evaluated using a small-volume (500 nl) conductivity cell (cell constant 5.1 × 10 3 m -1) which is described. It was then characterized using a factorial method and optimized to maximize the sensitivity (absolute change in frequency) to changes in conductivity. A novel method was used to determine the cell constant for a pair of microband electrodes (100 μm across on 200 μm centres) with electrolyte confined in a fine channel above them - this was 2615 ± 86 m -1 and the detector has been used with this cell for isotachophoretic separations reported elsewhere.

KW - Cell constant

KW - CMOS oscillator

KW - Conductivity

KW - Detector

KW - Electrode array

KW - Electroseparations

KW - Factorial design

KW - Isotachophoresis

KW - Microband electrodes

KW - Simplex optimization

U2 - 10.1088/0957-0233/11/3/311

DO - 10.1088/0957-0233/11/3/311

M3 - Article

SN - 0957-0233

VL - 11

SP - 244

EP - 251

JO - Measurement Science and Technology

JF - Measurement Science and Technology

IS - 3

ER -

A capacitively coupled conductivity detector for electroseparations

Abstract

Keywords

Access to Document

Fingerprint

Cite this