A case of confined placental mosaicism with double trisomy associated with stillbirth.

L R Goodfellow; G Batra; V Hall; E McHale; A E P Heazell

doi:10.1016/j.placenta.2011.06.008

A case of confined placental mosaicism with double trisomy associated with stillbirth.

L R Goodfellow, G Batra, V Hall, E McHale, A E P Heazell

Research output: Contribution to journal › Article › peer-review

Abstract

We present a case of stillbirth in which the fetus was well grown and karyotypically normal, but the placenta was morphologically abnormal and had confined placental mosaicism (CPM) for a double trisomy of chromosomes 12 and 15. A compilation of published cases of CPM reveals that whilst approximately 80% of pregnancies progress normally, there is an association with abnormal placental morphology, intrauterine growth restriction, fetal abnormalities and stillbirth. This case highlights the potential adverse effects of CPM and the benefit of placental examination in determining the cause of stillbirth.

Original language	English
Pages (from-to)	699-703
Number of pages	4
Journal	Placenta
Volume	32
Issue number	9
DOIs	https://doi.org/10.1016/j.placenta.2011.06.008
Publication status	Published - Sept 2011

Keywords

Confined placental mosaicism
Cytogenetics
Placenta
Placental mesenchymal dysplasia
Stillbirth

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.placenta.2011.06.008

Cite this

@article{0bd96b51b8aa49bda18fb4025826a091,

title = "A case of confined placental mosaicism with double trisomy associated with stillbirth.",

abstract = "We present a case of stillbirth in which the fetus was well grown and karyotypically normal, but the placenta was morphologically abnormal and had confined placental mosaicism (CPM) for a double trisomy of chromosomes 12 and 15. A compilation of published cases of CPM reveals that whilst approximately 80% of pregnancies progress normally, there is an association with abnormal placental morphology, intrauterine growth restriction, fetal abnormalities and stillbirth. This case highlights the potential adverse effects of CPM and the benefit of placental examination in determining the cause of stillbirth.",

keywords = "Confined placental mosaicism, Cytogenetics, Placenta, Placental mesenchymal dysplasia, Stillbirth",

author = "Goodfellow, {L R} and G Batra and V Hall and E McHale and Heazell, {A E P}",

year = "2011",

month = sep,

doi = "10.1016/j.placenta.2011.06.008",

language = "English",

volume = "32",

pages = "699--703",

journal = "Placenta",

issn = "1532-3102",

publisher = "W.B. Saunders Co. Ltd",

number = "9",

}

TY - JOUR

T1 - A case of confined placental mosaicism with double trisomy associated with stillbirth.

AU - Goodfellow, L R

AU - Batra, G

AU - Hall, V

AU - McHale, E

AU - Heazell, A E P

PY - 2011/9

Y1 - 2011/9

N2 - We present a case of stillbirth in which the fetus was well grown and karyotypically normal, but the placenta was morphologically abnormal and had confined placental mosaicism (CPM) for a double trisomy of chromosomes 12 and 15. A compilation of published cases of CPM reveals that whilst approximately 80% of pregnancies progress normally, there is an association with abnormal placental morphology, intrauterine growth restriction, fetal abnormalities and stillbirth. This case highlights the potential adverse effects of CPM and the benefit of placental examination in determining the cause of stillbirth.

AB - We present a case of stillbirth in which the fetus was well grown and karyotypically normal, but the placenta was morphologically abnormal and had confined placental mosaicism (CPM) for a double trisomy of chromosomes 12 and 15. A compilation of published cases of CPM reveals that whilst approximately 80% of pregnancies progress normally, there is an association with abnormal placental morphology, intrauterine growth restriction, fetal abnormalities and stillbirth. This case highlights the potential adverse effects of CPM and the benefit of placental examination in determining the cause of stillbirth.

KW - Confined placental mosaicism

KW - Cytogenetics

KW - Placenta

KW - Placental mesenchymal dysplasia

KW - Stillbirth

U2 - 10.1016/j.placenta.2011.06.008

DO - 10.1016/j.placenta.2011.06.008

M3 - Article

C2 - 21733574

SN - 1532-3102

VL - 32

SP - 699

EP - 703

JO - Placenta

JF - Placenta

IS - 9

ER -

A case of confined placental mosaicism with double trisomy associated with stillbirth.

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this