A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection.

Rachel J Lundie, Lauren Webb, Angela K Marley, Alexander Phythian-Adams, Peter Cook, Lucy H Jackson-Jones, Sheila Brown, Rick M Maizels, Louis Boon, Meredith O'Keeffe, Andrew MacDonald

    Research output: Contribution to journalArticlepeer-review


    Dendritic cells (DCs) are the key initiators of T helper (Th) 2 immune responses against the parasitic helminth Schistosoma mansoni. Although the liver is one of the main sites of Ag deposition during infection with this parasite, it is not yet clear how distinct DC subtypes in this tissue respond to S. mansoni Ags in vivo, or how the liver microenvironment might influence DC function during establishment of the Th2 response. In this study, we show that hepatic DC subsets undergo distinct activation processes in vivo following murine infection with S. mansoni. Conventional DCs (cDCs) from schistosome-infected mice up-regulated expression of the costimulatory molecule CD40 and were capable of priming naïve CD4(+) T cells, whereas plasmacytoid DCs (pDCs) up-regulated expression of MHC class II, CD86 and CD40 but were unable to support the expansion of either naïve or effector/memory CD4(+) T cells. Importantly, in vivo depletion of pDCs revealed that this subset was dispensable for either maintenance or regulation of the hepatic Th2 effector response during acute S. mansoni infection. Our data provides strong evidence that S. mansoni infection favours the establishment of an immunogenic, rather than tolerogenic, liver microenvironment that conditions cDCs to initiate and maintain Th2 immunity in the context of ongoing Ag exposure.Immunology and Cell Biology accepted article preview online, 11 December 2015. doi:10.1038/icb.2015.114.
    Original languageEnglish
    Pages (from-to)400-410
    Number of pages11
    JournalImmunology and cell biology
    Early online date12 Jan 2016
    Publication statusPublished - 2016


    Dive into the research topics of 'A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection.'. Together they form a unique fingerprint.

    Cite this