A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System

Aristides Dokoumetzidis, Panos Macheras

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Dissolution research started to develop about 100 years ago as a field of physical chemistry and since then important progress has been made. However, explicit interest in drug related dissolution has grown only since the realisation that dissolution is an important factor of drug bioavailability in the 1950s. This review attempts to account the most important developments in the field, from a historical point of view. It is structured in a chronological order, from the theoretical foundations of dissolution, developed in the first half of the 20th century, and the development of a relationship between dissolution and bioavailability in the 1950s, going to the more recent developments in the framework of the Biopharmaceutics Classification System (BCS). Research on relevant fields of pharmaceutical technology, like sustained release formulations, where drug dissolution plays an important role, is reviewed. The review concludes with the modern trends on drug dissolution research and their regulatory implications. © 2006 Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)1-11
    Number of pages10
    JournalInternational Journal of Pharmaceutics
    Volume321
    Issue number1-2
    Publication statusPublished - 14 Sept 2006

    Keywords

    • Bioavailability
    • Drug dissolution
    • Drug release

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