A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization: Findings from the COMPARE-UF Registry

Raymond M. Anchan; Daniel Wojdyla; Pietro Bortoletto; Kathryn Terry; Emily Disler; Ankrish Milne; Antonio Gargiulo; John Petrozza; Olga Brook; Serene Srouji; Cynthia C. Morton; James Greenberg; Ganesa Wegienka; Elizabeth A. Stewart; Wanda K. Nicholson; Laine Thomas; Sateria Venable; Shannon Laughlin-Tommaso; Michael P. Diamond; G. Larry Maxwell; Erica E. Marsh; Evan R. Myers; Anissa I. Vines; Lauren A. Wise; Kedra Wallace; Vanessa L. Jacoby; James B. Spies

doi:10.1089/jwh.2022.0133

A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization: Findings from the COMPARE-UF Registry

Raymond M. Anchan^*, Daniel Wojdyla, Pietro Bortoletto, Kathryn Terry, Emily Disler, Ankrish Milne, Antonio Gargiulo, John Petrozza, Olga Brook, Serene Srouji, Cynthia C. Morton, James Greenberg, Ganesa Wegienka, Elizabeth A. Stewart, Wanda K. Nicholson, Laine Thomas, Sateria Venable, Shannon Laughlin-Tommaso, Michael P. Diamond, G. Larry MaxwellErica E. Marsh, Evan R. Myers, Anissa I. Vines, Lauren A. Wise, Kedra Wallace, Vanessa L. Jacoby, James B. Spies

^*Corresponding author for this work

Division of Psychology Communication and Human Neuroscience (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To compare 12-month post-treatment health-related quality of life (HR-QoL) and symptom severity (SS) changes among patients with symptomatic uterine fibroids (SUF) not seeking fertility and undergo a hysterectomy, abdominal myomectomy (AM), or uterine artery embolization (UAE). Materials and Methods: The Comparing Options for Management: Patient-Centered Results for Uterine Fibroids (COMPARE-UF) Registry is a multi-institutional prospective observational cohort study of patients treated for SUF. A subset of 1465 women 31-45 years of age, who underwent either hysterectomy (n = 741), AM (n = 446), or UAE (n = 155) were included in this analysis. Demographics, fibroid history, and symptoms were obtained by baseline questionnaires and at 1 year post-treatment. Results were stratified by all treatments and propensity score weighting to adjust for differences in baseline characteristics. Results: Women undergoing UAE reported the lowest baseline HR-QoL and highest SS scores (mean = 40.6 [standard deviation (SD) = 23.8]; 62.3 [SD = 24.2]) followed by hysterectomy (44.3 [24.3]; 59.8 [SD = 24.1]). At 12 months, women who underwent a hysterectomy experienced the largest change in both HR-QoL (48.7 [26.2]) and SS (51.9 [25.6]) followed by other uterine-sparing treatments. Propensity score weighting revealed all treatments produced substantial improvement, with hysterectomy patients reporting the highest HR-QoL score (92.0 [17.8]) compared with myomectomy (86.7 [17.2]) and UAE (82.6 [21.5]) (p < 0.0001). Similarly, hysterectomy patients reported the lowest SS scores (8.2 [15.1]) compared with myomectomy (16.5 [15.1]) and UAE (19.6 [17.5]) (p < 0.0001). Conclusion: All procedures showed improvement in HR-QoL and reduction in SS score at 12 months, hysterectomy showing maximum improvement. Of importance, at 12 months, patients who underwent either a myomectomy or UAE reported comparable symptom relief and HR-QoL.

Original language	English
Pages (from-to)	423-433
Number of pages	11
Journal	Journal of Women's Health
Volume	32
Issue number	4
Early online date	13 Jan 2023
DOIs	https://doi.org/10.1089/jwh.2022.0133
Publication status	Published - 1 Apr 2023

Keywords

hysterectomy
myomectomy
quality of life
uterine artery embolization
uterine fibroids

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10.1089/jwh.2022.0133

Cite this

Anchan, R. M., Wojdyla, D., Bortoletto, P., Terry, K., Disler, E., Milne, A., Gargiulo, A., Petrozza, J., Brook, O., Srouji, S., Morton, C. C., Greenberg, J., Wegienka, G., Stewart, E. A., Nicholson, W. K., Thomas, L., Venable, S., Laughlin-Tommaso, S., Diamond, M. P., ... Spies, J. B. (2023). A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization: Findings from the COMPARE-UF Registry. Journal of Women's Health, 32(4), 423-433. https://doi.org/10.1089/jwh.2022.0133

@article{f6a78fbca0ca443185c92bfb8b238efb,

title = "A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization: Findings from the COMPARE-UF Registry",

abstract = "Objective: To compare 12-month post-treatment health-related quality of life (HR-QoL) and symptom severity (SS) changes among patients with symptomatic uterine fibroids (SUF) not seeking fertility and undergo a hysterectomy, abdominal myomectomy (AM), or uterine artery embolization (UAE). Materials and Methods: The Comparing Options for Management: Patient-Centered Results for Uterine Fibroids (COMPARE-UF) Registry is a multi-institutional prospective observational cohort study of patients treated for SUF. A subset of 1465 women 31-45 years of age, who underwent either hysterectomy (n = 741), AM (n = 446), or UAE (n = 155) were included in this analysis. Demographics, fibroid history, and symptoms were obtained by baseline questionnaires and at 1 year post-treatment. Results were stratified by all treatments and propensity score weighting to adjust for differences in baseline characteristics. Results: Women undergoing UAE reported the lowest baseline HR-QoL and highest SS scores (mean = 40.6 [standard deviation (SD) = 23.8]; 62.3 [SD = 24.2]) followed by hysterectomy (44.3 [24.3]; 59.8 [SD = 24.1]). At 12 months, women who underwent a hysterectomy experienced the largest change in both HR-QoL (48.7 [26.2]) and SS (51.9 [25.6]) followed by other uterine-sparing treatments. Propensity score weighting revealed all treatments produced substantial improvement, with hysterectomy patients reporting the highest HR-QoL score (92.0 [17.8]) compared with myomectomy (86.7 [17.2]) and UAE (82.6 [21.5]) (p < 0.0001). Similarly, hysterectomy patients reported the lowest SS scores (8.2 [15.1]) compared with myomectomy (16.5 [15.1]) and UAE (19.6 [17.5]) (p < 0.0001). Conclusion: All procedures showed improvement in HR-QoL and reduction in SS score at 12 months, hysterectomy showing maximum improvement. Of importance, at 12 months, patients who underwent either a myomectomy or UAE reported comparable symptom relief and HR-QoL.",

keywords = "hysterectomy, myomectomy, quality of life, uterine artery embolization, uterine fibroids",

author = "Anchan, {Raymond M.} and Daniel Wojdyla and Pietro Bortoletto and Kathryn Terry and Emily Disler and Ankrish Milne and Antonio Gargiulo and John Petrozza and Olga Brook and Serene Srouji and Morton, {Cynthia C.} and James Greenberg and Ganesa Wegienka and Stewart, {Elizabeth A.} and Nicholson, {Wanda K.} and Laine Thomas and Sateria Venable and Shannon Laughlin-Tommaso and Diamond, {Michael P.} and Maxwell, {G. Larry} and Marsh, {Erica E.} and Myers, {Evan R.} and Vines, {Anissa I.} and Wise, {Lauren A.} and Kedra Wallace and Jacoby, {Vanessa L.} and Spies, {James B.}",

note = "Funding Information: M.P.D. reports grants from AbbVie, Bayer, and ObsEva outside the submitted work. Funding Information: S.L.-T. reports grants from Bayer and personal fees from Allergan Pharma and UpToDate outside the submitted work. Publisher Copyright: Copyright {\textcopyright} 2023, Mary Ann Liebert, Inc.",

year = "2023",

month = apr,

day = "1",

doi = "10.1089/jwh.2022.0133",

language = "English",

volume = "32",

pages = "423--433",

journal = "Journal of Women's Health",

issn = "1540-9996",

publisher = "Mary Ann Liebert Incorporated",

number = "4",

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Anchan, RM, Wojdyla, D, Bortoletto, P, Terry, K, Disler, E, Milne, A, Gargiulo, A, Petrozza, J, Brook, O, Srouji, S, Morton, CC, Greenberg, J, Wegienka, G, Stewart, EA, Nicholson, WK, Thomas, L, Venable, S, Laughlin-Tommaso, S, Diamond, MP, Maxwell, GL, Marsh, EE, Myers, ER, Vines, AI, Wise, LA, Wallace, K, Jacoby, VL & Spies, JB 2023, 'A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization: Findings from the COMPARE-UF Registry', Journal of Women's Health, vol. 32, no. 4, pp. 423-433. https://doi.org/10.1089/jwh.2022.0133

TY - JOUR

T1 - A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization

T2 - Findings from the COMPARE-UF Registry

AU - Anchan, Raymond M.

AU - Wojdyla, Daniel

AU - Bortoletto, Pietro

AU - Terry, Kathryn

AU - Disler, Emily

AU - Milne, Ankrish

AU - Gargiulo, Antonio

AU - Petrozza, John

AU - Brook, Olga

AU - Srouji, Serene

AU - Morton, Cynthia C.

AU - Greenberg, James

AU - Wegienka, Ganesa

AU - Stewart, Elizabeth A.

AU - Nicholson, Wanda K.

AU - Thomas, Laine

AU - Venable, Sateria

AU - Laughlin-Tommaso, Shannon

AU - Diamond, Michael P.

AU - Maxwell, G. Larry

AU - Marsh, Erica E.

AU - Myers, Evan R.

AU - Vines, Anissa I.

AU - Wise, Lauren A.

AU - Wallace, Kedra

AU - Jacoby, Vanessa L.

AU - Spies, James B.

N1 - Funding Information: M.P.D. reports grants from AbbVie, Bayer, and ObsEva outside the submitted work. Funding Information: S.L.-T. reports grants from Bayer and personal fees from Allergan Pharma and UpToDate outside the submitted work. Publisher Copyright: Copyright © 2023, Mary Ann Liebert, Inc.

PY - 2023/4/1

Y1 - 2023/4/1

N2 - Objective: To compare 12-month post-treatment health-related quality of life (HR-QoL) and symptom severity (SS) changes among patients with symptomatic uterine fibroids (SUF) not seeking fertility and undergo a hysterectomy, abdominal myomectomy (AM), or uterine artery embolization (UAE). Materials and Methods: The Comparing Options for Management: Patient-Centered Results for Uterine Fibroids (COMPARE-UF) Registry is a multi-institutional prospective observational cohort study of patients treated for SUF. A subset of 1465 women 31-45 years of age, who underwent either hysterectomy (n = 741), AM (n = 446), or UAE (n = 155) were included in this analysis. Demographics, fibroid history, and symptoms were obtained by baseline questionnaires and at 1 year post-treatment. Results were stratified by all treatments and propensity score weighting to adjust for differences in baseline characteristics. Results: Women undergoing UAE reported the lowest baseline HR-QoL and highest SS scores (mean = 40.6 [standard deviation (SD) = 23.8]; 62.3 [SD = 24.2]) followed by hysterectomy (44.3 [24.3]; 59.8 [SD = 24.1]). At 12 months, women who underwent a hysterectomy experienced the largest change in both HR-QoL (48.7 [26.2]) and SS (51.9 [25.6]) followed by other uterine-sparing treatments. Propensity score weighting revealed all treatments produced substantial improvement, with hysterectomy patients reporting the highest HR-QoL score (92.0 [17.8]) compared with myomectomy (86.7 [17.2]) and UAE (82.6 [21.5]) (p < 0.0001). Similarly, hysterectomy patients reported the lowest SS scores (8.2 [15.1]) compared with myomectomy (16.5 [15.1]) and UAE (19.6 [17.5]) (p < 0.0001). Conclusion: All procedures showed improvement in HR-QoL and reduction in SS score at 12 months, hysterectomy showing maximum improvement. Of importance, at 12 months, patients who underwent either a myomectomy or UAE reported comparable symptom relief and HR-QoL.

AB - Objective: To compare 12-month post-treatment health-related quality of life (HR-QoL) and symptom severity (SS) changes among patients with symptomatic uterine fibroids (SUF) not seeking fertility and undergo a hysterectomy, abdominal myomectomy (AM), or uterine artery embolization (UAE). Materials and Methods: The Comparing Options for Management: Patient-Centered Results for Uterine Fibroids (COMPARE-UF) Registry is a multi-institutional prospective observational cohort study of patients treated for SUF. A subset of 1465 women 31-45 years of age, who underwent either hysterectomy (n = 741), AM (n = 446), or UAE (n = 155) were included in this analysis. Demographics, fibroid history, and symptoms were obtained by baseline questionnaires and at 1 year post-treatment. Results were stratified by all treatments and propensity score weighting to adjust for differences in baseline characteristics. Results: Women undergoing UAE reported the lowest baseline HR-QoL and highest SS scores (mean = 40.6 [standard deviation (SD) = 23.8]; 62.3 [SD = 24.2]) followed by hysterectomy (44.3 [24.3]; 59.8 [SD = 24.1]). At 12 months, women who underwent a hysterectomy experienced the largest change in both HR-QoL (48.7 [26.2]) and SS (51.9 [25.6]) followed by other uterine-sparing treatments. Propensity score weighting revealed all treatments produced substantial improvement, with hysterectomy patients reporting the highest HR-QoL score (92.0 [17.8]) compared with myomectomy (86.7 [17.2]) and UAE (82.6 [21.5]) (p < 0.0001). Similarly, hysterectomy patients reported the lowest SS scores (8.2 [15.1]) compared with myomectomy (16.5 [15.1]) and UAE (19.6 [17.5]) (p < 0.0001). Conclusion: All procedures showed improvement in HR-QoL and reduction in SS score at 12 months, hysterectomy showing maximum improvement. Of importance, at 12 months, patients who underwent either a myomectomy or UAE reported comparable symptom relief and HR-QoL.

KW - hysterectomy

KW - myomectomy

KW - quality of life

KW - uterine artery embolization

KW - uterine fibroids

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UR - https://www.mendeley.com/catalogue/16d688be-571a-3f7b-9f1c-b1a6a4742c90/

U2 - 10.1089/jwh.2022.0133

DO - 10.1089/jwh.2022.0133

M3 - Article

C2 - 36637808

AN - SCOPUS:85152173848

SN - 1540-9996

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EP - 433

JO - Journal of Women's Health

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A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization: Findings from the COMPARE-UF Registry

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Keywords

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A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization: Findings from the COMPARE-UF Registry

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