A comparative analysis of kinetic models of erythrocyte glycolysis

F. B. du Preez; R. Conradie; G. P. Penkler; K. Holm; F. L J van Dooren; J. L. Snoep

doi:10.1016/j.jtbi.2007.10.006

A comparative analysis of kinetic models of erythrocyte glycolysis

F. B. du Preez, R. Conradie, G. P. Penkler, K. Holm, F. L J van Dooren, J. L. Snoep

Research output: Contribution to journal › Article › peer-review

Abstract

Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. © 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	488-496
Number of pages	8
Journal	Journal of Theoretical Biology
Volume	252
Issue number	3
DOIs	https://doi.org/10.1016/j.jtbi.2007.10.006
Publication status	Published - 7 Jun 2008

Keywords

JWS online
Metabolic control analysis
Model comparison
Rate characteristics
Supply-demand analysis

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10.1016/j.jtbi.2007.10.006

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title = "A comparative analysis of kinetic models of erythrocyte glycolysis",

abstract = "Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. {\textcopyright} 2007 Elsevier Ltd. All rights reserved.",

keywords = "JWS online, Metabolic control analysis, Model comparison, Rate characteristics, Supply-demand analysis",

author = "{du Preez}, {F. B.} and R. Conradie and Penkler, {G. P.} and K. Holm and {van Dooren}, {F. L J} and Snoep, {J. L.}",

year = "2008",

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day = "7",

doi = "10.1016/j.jtbi.2007.10.006",

language = "English",

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journal = "Journal of Theoretical Biology",

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T1 - A comparative analysis of kinetic models of erythrocyte glycolysis

AU - du Preez, F. B.

AU - Conradie, R.

AU - Penkler, G. P.

AU - Holm, K.

AU - van Dooren, F. L J

AU - Snoep, J. L.

PY - 2008/6/7

Y1 - 2008/6/7

N2 - Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. © 2007 Elsevier Ltd. All rights reserved.

AB - Since the 1970s, with Heinrich as a pioneer in the field, numerous kinetic models of erythrocyte glycolysis have been constructed. A functional comparison of eight of these models indicates that the production of ATP and GSH in the red blood cell is largely controlled by the demand reactions. The rate characteristics for the supply and demand blocks indicate a good homeostatic control of ATP and GSH concentrations at different work loads for the pathway, while the production rates of ATP and GSH can be adjusted as needed by the demand reactions. © 2007 Elsevier Ltd. All rights reserved.

KW - JWS online

KW - Metabolic control analysis

KW - Model comparison

KW - Rate characteristics

KW - Supply-demand analysis

U2 - 10.1016/j.jtbi.2007.10.006

DO - 10.1016/j.jtbi.2007.10.006

M3 - Article

SN - 0022-5193

VL - 252

SP - 488

EP - 496

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

IS - 3

ER -

A comparative analysis of kinetic models of erythrocyte glycolysis

Abstract

Keywords

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