A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32

J H Weis; C C Morton; G A Bruns; J J Weis; L B Klickstein; W W Wong; D T Fearon

A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32

J H Weis, C C Morton, G A Bruns, J J Weis, L B Klickstein, W W Wong, D T Fearon

Division of Evolution, Infection and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

The alternative or classical pathways for complement system component C3 may be triggered by microorganisms and antigen-antibody complexes. In particular, an activated fragment of C3, C3b, covalently attaches to microorganisms or antigen-antibody complexes, which in turn bind to the C3b receptor, also known as complement receptor 1. The genes encoding the proteins that constitute the C3-activating enzymes have been cloned and mapped to a "complement activation" locus in the major histocompatibility complex, and we demonstrate in this study such a locus on the long arm of chromosome 1 at band 1q32.

Original language	English
Pages (from-to)	312-5
Number of pages	4
Journal	Journal of immunology (Baltimore, Md. : 1950)
Volume	138
Issue number	1
Publication status	Published - 1 Jan 1987

Keywords

Chromosome Mapping
Chromosomes, Human, Pair 1
Genes
Humans
Nucleic Acid Hybridization
Receptors, Complement
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Cite this

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title = "A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32",

abstract = "The alternative or classical pathways for complement system component C3 may be triggered by microorganisms and antigen-antibody complexes. In particular, an activated fragment of C3, C3b, covalently attaches to microorganisms or antigen-antibody complexes, which in turn bind to the C3b receptor, also known as complement receptor 1. The genes encoding the proteins that constitute the C3-activating enzymes have been cloned and mapped to a {"}complement activation{"} locus in the major histocompatibility complex, and we demonstrate in this study such a locus on the long arm of chromosome 1 at band 1q32.",

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author = "Weis, {J H} and Morton, {C C} and Bruns, {G A} and Weis, {J J} and Klickstein, {L B} and Wong, {W W} and Fearon, {D T}",

year = "1987",

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language = "English",

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pages = "312--5",

journal = "Journal of immunology (Baltimore, Md. : 1950)",

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T1 - A complement receptor locus

T2 - genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32

AU - Weis, J H

AU - Morton, C C

AU - Bruns, G A

AU - Weis, J J

AU - Klickstein, L B

AU - Wong, W W

AU - Fearon, D T

PY - 1987/1/1

Y1 - 1987/1/1

N2 - The alternative or classical pathways for complement system component C3 may be triggered by microorganisms and antigen-antibody complexes. In particular, an activated fragment of C3, C3b, covalently attaches to microorganisms or antigen-antibody complexes, which in turn bind to the C3b receptor, also known as complement receptor 1. The genes encoding the proteins that constitute the C3-activating enzymes have been cloned and mapped to a "complement activation" locus in the major histocompatibility complex, and we demonstrate in this study such a locus on the long arm of chromosome 1 at band 1q32.

AB - The alternative or classical pathways for complement system component C3 may be triggered by microorganisms and antigen-antibody complexes. In particular, an activated fragment of C3, C3b, covalently attaches to microorganisms or antigen-antibody complexes, which in turn bind to the C3b receptor, also known as complement receptor 1. The genes encoding the proteins that constitute the C3-activating enzymes have been cloned and mapped to a "complement activation" locus in the major histocompatibility complex, and we demonstrate in this study such a locus on the long arm of chromosome 1 at band 1q32.

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 1

KW - Genes

KW - Humans

KW - Nucleic Acid Hybridization

KW - Receptors, Complement

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, P.H.S.

M3 - Article

C2 - 3782802

SN - 0022-1767

VL - 138

SP - 312

EP - 315

JO - Journal of immunology (Baltimore, Md. : 1950)

JF - Journal of immunology (Baltimore, Md. : 1950)

IS - 1

ER -

A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32

Abstract

Keywords

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