A core promoter element downstream of the TATA box that is recognized by TFIIB

Wensheng Deng; Stefan G E Roberts

doi:10.1101/gad.342405

A core promoter element downstream of the TATA box that is recognized by TFIIB

Wensheng Deng, Stefan G E Roberts

Research output: Contribution to journal › Article › peer-review

Abstract

We have defined a core promoter element downstream of the TATA box that is recognized by TFIIB. This involves a DNA-binding domain in TFIIB that is distinct from the helix-turn-helix motif (which recognizes an element upstream of the TATA box). The TFIIB recognition element we describe regulates transcription in a manner that is promoter context-dependent, particularly with respect to the TFIIB recognition element that is located upstream of the TATA box. Thus TFIIB can recognize two distinct sequence elements that flank the TATA box, employing independent DNA-binding motifs and cooperating in the regulation of transcription. © 2005 by Cold Spring Harbor Laboratory Press.

Original language	English
Pages (from-to)	2418-2423
Number of pages	5
Journal	Genes and development
Volume	19
Issue number	20
DOIs	https://doi.org/10.1101/gad.342405
Publication status	Published - 15 Oct 2005

Keywords

Promoter
RNA polymerase II
TFIIB
Transcription

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10.1101/gad.342405

http://www.genesdev.org/cgi/reprint/19/20/2418

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title = "A core promoter element downstream of the TATA box that is recognized by TFIIB",

abstract = "We have defined a core promoter element downstream of the TATA box that is recognized by TFIIB. This involves a DNA-binding domain in TFIIB that is distinct from the helix-turn-helix motif (which recognizes an element upstream of the TATA box). The TFIIB recognition element we describe regulates transcription in a manner that is promoter context-dependent, particularly with respect to the TFIIB recognition element that is located upstream of the TATA box. Thus TFIIB can recognize two distinct sequence elements that flank the TATA box, employing independent DNA-binding motifs and cooperating in the regulation of transcription. {\textcopyright} 2005 by Cold Spring Harbor Laboratory Press.",

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author = "Wensheng Deng and Roberts, {Stefan G E}",

year = "2005",

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AU - Roberts, Stefan G E

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N2 - We have defined a core promoter element downstream of the TATA box that is recognized by TFIIB. This involves a DNA-binding domain in TFIIB that is distinct from the helix-turn-helix motif (which recognizes an element upstream of the TATA box). The TFIIB recognition element we describe regulates transcription in a manner that is promoter context-dependent, particularly with respect to the TFIIB recognition element that is located upstream of the TATA box. Thus TFIIB can recognize two distinct sequence elements that flank the TATA box, employing independent DNA-binding motifs and cooperating in the regulation of transcription. © 2005 by Cold Spring Harbor Laboratory Press.

AB - We have defined a core promoter element downstream of the TATA box that is recognized by TFIIB. This involves a DNA-binding domain in TFIIB that is distinct from the helix-turn-helix motif (which recognizes an element upstream of the TATA box). The TFIIB recognition element we describe regulates transcription in a manner that is promoter context-dependent, particularly with respect to the TFIIB recognition element that is located upstream of the TATA box. Thus TFIIB can recognize two distinct sequence elements that flank the TATA box, employing independent DNA-binding motifs and cooperating in the regulation of transcription. © 2005 by Cold Spring Harbor Laboratory Press.

KW - Promoter

KW - RNA polymerase II

KW - TFIIB

KW - Transcription

U2 - 10.1101/gad.342405

DO - 10.1101/gad.342405

M3 - Article

SN - 0890-9369

VL - 19

SP - 2418

EP - 2423

JO - Genes and development

JF - Genes and development

IS - 20

ER -

A core promoter element downstream of the TATA box that is recognized by TFIIB

Abstract

Keywords

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