A Crohn's disease-associated insertion polymorphism (3020insC) in the NOD2 gene is not associated with psoriasis vulgaris, palmo-plantar pustular psoriasis or guttate psoriasis

C. Young, M. H. Allen, A. Cuthbert, M. Ameen, C. Veal, J. Leman, A. D. Burden, B. Kirby, C. E M Griffiths, R. C. Trembath, C. G. Mathew, Jonathan N W N Barker

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A C-insertion polymorphism in the NOD2 gene (3020insC) on chromosome 16 is a rare mutation associated with Crohn's disease. Crohn's disease and psoriasis are more commonly observed together than expected by chance. Furthermore a susceptibility locus for psoriasis has been identified on chromosome 16q which overlaps the recently identified susceptibility locus for Crohn's disease. Thus, NOD2 may potentially be important as a candidate susceptibility gene for psoriasis. We tested this hypothesis by genotyping psoriasis patients for the C-insertion polymorphism using the Taqman ABI 7700 sequencing system. No statistically significant differences were observed between psoriasis vulgaris (n = 216), palmo-plantar pustular psoriasis (PPP) (n = 100), guttate psoriasis (n = 118) and the control group (n = 283). In both patient and control groups, no mutant homozygotes were observed and approximately 4% were heterozygotes. This particular insertion mutation in the NOD2 gene does not appear to contribute to the genetic susceptibility of psoriasis vulgaris, PPP or guttate psoriasis. However, other mutations exist in the NOD2 gene, which may potentially have a role in psoriasis susceptibility. © Blackwell Munksgaard, 2003.
    Original languageEnglish
    Pages (from-to)506-509
    Number of pages3
    JournalExperimental Dermatology
    Volume12
    Issue number4
    DOIs
    Publication statusPublished - Aug 2003

    Keywords

    • Chromosome 16
    • Crohn's disease
    • Genetics
    • NOD2
    • Psoriasis

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