A DFT mechanistic study of the organocatalytic asymmetric reaction of aldehydes and homophthalic anhydride

Cristina Trujillo, Isabel Rozas*, Astrid Botte, Stephen J. Connon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The first DFT study of the cycloaddition of benzaldehyde with homophthalic anhydride under the influence of a bifunctional organocatalyst is reported. The catalyst first binds and then deprotonates the anhydride, leading to a squaramide-bound enolate, which then adds to the aldehyde with activation of the electrophile by the catalyst's ammonium ion.

Original languageEnglish
Pages (from-to)8874-8877
Number of pages4
JournalChemical Communications
Volume53
Issue number63
DOIs
Publication statusPublished - 2017

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