A dialdehyde cyclization cascade: An approach to pleuromutilin

Matthew D. Helm, Madeleine Da Silva, David Sucunza, Thomas J K Findley, David J. Procter

    Research output: Contribution to journalArticlepeer-review


    Chamical Equation Presentation Waiting in line: Aldehyde groups take turns reacting in a Sml2-mediated cyclization cascade to form the skeleton 2 of the antibacterial natural product pleuro-mutilin. Two rings and four contiguous stereocenters are constructed during the cascade with complete diastereocontrol. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.
    Original languageEnglish
    Pages (from-to)9315-9317
    Number of pages2
    JournalAngewandte Chemie - International Edition
    Issue number49
    Publication statusPublished - 23 Nov 2009


    • Natural products
    • Radical reactions
    • Samarium
    • Total synthesis


    Dive into the research topics of 'A dialdehyde cyclization cascade: An approach to pleuromutilin'. Together they form a unique fingerprint.

    Cite this