A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles

Anna Rita Bilia; M. Camilla Bergonzi; Francesco F. Vincieri; Pierandrea Lo Nostro; Gareth A. Morris

doi:10.1002/jps.10217

A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles

Anna Rita Bilia, M. Camilla Bergonzi, Francesco F. Vincieri, Pierandrea Lo Nostro, Gareth A. Morris

Research output: Contribution to journal › Article › peer-review

Abstract

Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation. © 2002 Wiley-Liss, Inc.

Original language	English
Pages (from-to)	2265-2270
Number of pages	5
Journal	Journal of Pharmaceutical Sciences
Volume	91
Issue number	10
DOIs	https://doi.org/10.1002/jps.10217
Publication status	Published - Oct 2002

Keywords

Artemisinin
DOSY
Micellar solubilization
Micelle(s)
Vitamin C

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10.1002/jps.10217

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title = "A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles",

abstract = "Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation. {\textcopyright} 2002 Wiley-Liss, Inc.",

keywords = "Artemisinin, DOSY, Micellar solubilization, Micelle(s), Vitamin C",

author = "Bilia, {Anna Rita} and {Camilla Bergonzi}, M. and Vincieri, {Francesco F.} and {Lo Nostro}, Pierandrea and Morris, {Gareth A.}",

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AU - Bilia, Anna Rita

AU - Camilla Bergonzi, M.

AU - Vincieri, Francesco F.

AU - Lo Nostro, Pierandrea

AU - Morris, Gareth A.

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N2 - Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation. © 2002 Wiley-Liss, Inc.

AB - Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation. © 2002 Wiley-Liss, Inc.

KW - Artemisinin

KW - DOSY

KW - Micellar solubilization

KW - Micelle(s)

KW - Vitamin C

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DO - 10.1002/jps.10217

M3 - Article

SN - 0022-3549

VL - 91

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JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

IS - 10

ER -

A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles

Abstract

Keywords

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