A diverse spectrum of mycoses histologically diagnosed in Ghana: Insights from a 10-year retrospective study

Bright Katey Ocansey, Isaac Joe Erskine, Leonard Okine, Daniel Potakey, Prince Pappoe-Ashong, Isaac Sraku, Solomon Edward Quayson, Japheth Awuletey Opintan, Chris Kosmidis, David Wemyss Denning

Research output: Other contributionpeer-review


In Ghana, most laboratory diagnoses of severe mycoses are based on histopathology findings due to inadequate availability of serology, culture, and molecular tests. The aim of this study was to evaluate the spectrum of mycoses diagnosed in Ghana. We retrospectively reviewed reports from 2012 to 2021 from three major pathology laboratories in Ghana to identify reports indicating the presence of fungal elements and diagnosis of a mycosis, then extracted demographic, clinical history, site of infection, stain(s), used and diagnosed mycosis details. Over the 10-year period, 107 cases were found. No apparent increasing and decreasing trend in the number of cases per year or in a period was observed. The age range of affected patients was from 4 to 86 years. Special stains for fungi were only used in 22 of 107 (20.6%) of cases. The most frequently affected site was the sino-nasal area (34%). Mycosis type was determined for 58 (54.2%) cases, comprising aspergillosis (21), candidiasis (14), dermatophytosis (6), mucormycosis (3), two cases each of chromoblastomycosis, histoplasmosis, eumycetoma, entomophthoromycosis, sporotrichosis, and Malassezia infection and a single case each of cryptococcosis and deep onychomycosis. Of the 53 (49.5%) cases with presumptive diagnosis data, only seven (13.2%) had a pre-biopsy suspicion of mycosis. There is a wide spectrum of mycoses in Ghana, including endemic mycoses not previously reported. Improving the use of special fungal stains could increase yield and mycoses identification. Laboratory diagnostic capacity needs enhancement to complement histopathology investigations with serology, culture, and molecular methods.

Original languageEnglish
Publication statusPublished - 7 Mar 2024

Publication series

NameMedical mycology
ISSN (Print)1369-3786


  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aspergillosis/veterinary
  • Child
  • Child, Preschool
  • Ghana/epidemiology
  • Histoplasmosis/veterinary
  • Humans
  • Middle Aged
  • Mycoses/pathology
  • Retrospective Studies
  • Young Adult


Dive into the research topics of 'A diverse spectrum of mycoses histologically diagnosed in Ghana: Insights from a 10-year retrospective study'. Together they form a unique fingerprint.

Cite this