A Dual Photoredox-Nickel Strategy for Remote Functionalization via Iminyl Radicals: Radical Ring-Opening–Arylation, –Vinylation and –Alkylation Cascades

Elizabeth Dauncey, Shashikant U. Dighe, James J Douglas, Daniele Leonori

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    Abstract

    A divergent strategy for the remote arylation, vinylation and alkylation of nitriles is described. These processes proceed through the photoredox generation of a cyclic iminyl radical and its following ring-opening reaction. The distal nitrile radical is then engaged in nickel-based catalytic cycles to form C–C bonds with aryl bromides, alkynes and alkyl bromides.
    Original languageEnglish
    JournalChemical Science
    Issue number33
    Early online date27 Jun 2019
    DOIs
    Publication statusPublished - 2019

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