A fluorous, pummerer cyclative-capture strategy for the synthesis of N-heterocycles

Laura A. McAllister, Rosemary A. McCormick, Karen M. James, Stephen Brand, Nigel Willetts, David J. Procter

    Research output: Contribution to journalArticlepeer-review


    A fluorous, cyclative-capture strategy based on a new Pummerer cyclization process allows rapid access to tagged, heterocyclic frameworks. Convenient modification of the fluorous, heterocyclic scaffolds by using a variety of approaches including Pd-catalyzed cross-couplings is possible. Traceless, reductive cleavage of the fluorous-phase tag or oxidative cleavage and further elaboration, completes a strategy for the high-throughput, fluorous-phase synthesis of a diverse range of N-heterocycles. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)1032-1046
    Number of pages14
    JournalChemistry - A European Journal
    Issue number4
    Publication statusPublished - 2007


    • Fluorous-phase synthesis
    • Heterocycles
    • Organic synthesis
    • Pummerer reaction
    • Samarium


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