A fluorous, pummerer cyclative-capture strategy for the synthesis of N-heterocycles

Laura A. McAllister; Rosemary A. McCormick; Karen M. James; Stephen Brand; Nigel Willetts; David J. Procter

doi:10.1002/chem.200601429

A fluorous, pummerer cyclative-capture strategy for the synthesis of N-heterocycles

Laura A. McAllister, Rosemary A. McCormick, Karen M. James, Stephen Brand, Nigel Willetts, David J. Procter

Research output: Contribution to journal › Article › peer-review

Abstract

A fluorous, cyclative-capture strategy based on a new Pummerer cyclization process allows rapid access to tagged, heterocyclic frameworks. Convenient modification of the fluorous, heterocyclic scaffolds by using a variety of approaches including Pd-catalyzed cross-couplings is possible. Traceless, reductive cleavage of the fluorous-phase tag or oxidative cleavage and further elaboration, completes a strategy for the high-throughput, fluorous-phase synthesis of a diverse range of N-heterocycles. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	1032-1046
Number of pages	14
Journal	Chemistry - A European Journal
Volume	13
Issue number	4
DOIs	https://doi.org/10.1002/chem.200601429
Publication status	Published - 2007

Keywords

Fluorous-phase synthesis
Heterocycles
Organic synthesis
Pummerer reaction
Samarium

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10.1002/chem.200601429

Organic Materials Innovation Centre (OMIC)
Turner, M. (Participant), Yeates, S. (Participant), (Participant), (Participant), Collison, D. (Participant), Procter, D. (Participant) & (Participant)
Impact: Technological, Economic, Society and culture

Cite this

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title = "A fluorous, pummerer cyclative-capture strategy for the synthesis of N-heterocycles",

abstract = "A fluorous, cyclative-capture strategy based on a new Pummerer cyclization process allows rapid access to tagged, heterocyclic frameworks. Convenient modification of the fluorous, heterocyclic scaffolds by using a variety of approaches including Pd-catalyzed cross-couplings is possible. Traceless, reductive cleavage of the fluorous-phase tag or oxidative cleavage and further elaboration, completes a strategy for the high-throughput, fluorous-phase synthesis of a diverse range of N-heterocycles. {\textcopyright} 2007 Wiley-VCH Verlag GmbH & Co. KGaA.",

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AU - James, Karen M.

AU - Brand, Stephen

AU - Willetts, Nigel

AU - Procter, David J.

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AB - A fluorous, cyclative-capture strategy based on a new Pummerer cyclization process allows rapid access to tagged, heterocyclic frameworks. Convenient modification of the fluorous, heterocyclic scaffolds by using a variety of approaches including Pd-catalyzed cross-couplings is possible. Traceless, reductive cleavage of the fluorous-phase tag or oxidative cleavage and further elaboration, completes a strategy for the high-throughput, fluorous-phase synthesis of a diverse range of N-heterocycles. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

KW - Fluorous-phase synthesis

KW - Heterocycles

KW - Organic synthesis

KW - Pummerer reaction

KW - Samarium

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M3 - Article

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

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ER -

A fluorous, pummerer cyclative-capture strategy for the synthesis of N-heterocycles

Abstract

Keywords

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Organic Materials Innovation Centre (OMIC)

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