A focused scanning vertical beam for charged particle irradiation of living cells with single counted particles.

M M Merchant; JCJ Jeynes; GW Grime; V Palitsin; IDC Tullis; P Barber; B Vojnovic; RP Webb; Karen Kirkby

doi:10.1667/RR2847.1

A focused scanning vertical beam for charged particle irradiation of living cells with single counted particles.

M M Merchant, JCJ Jeynes, GW Grime, V Palitsin, IDC Tullis, P Barber, B Vojnovic, RP Webb, Karen Kirkby

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

The Surrey vertical beam is a new facility for targeted irradiation of cells in medium with singly counted ions. A duo-plasmatron ion source and a 2 MV Tandem™ accelerator supply a range of ions from protons to calcium for this beamline and microscope endstation, with energy ranges from 0.5 to 12 MeV. A magnetic quadrupole triplet lens is used to focus the beam of ions. We present the design of this beamline, and early results showing the capability to count single ions with 98% certainty on CR-39 track etch. We also show that the beam targeting accuracy is within 5 μm and selectively target human fibroblasts with a

Original language	English
Journal	Radiation Research
Volume	178
Issue number	3
DOIs	https://doi.org/10.1667/RR2847.1
Publication status	Published - Sept 2012

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abstract = "The Surrey vertical beam is a new facility for targeted irradiation of cells in medium with singly counted ions. A duo-plasmatron ion source and a 2 MV Tandem{\texttrademark} accelerator supply a range of ions from protons to calcium for this beamline and microscope endstation, with energy ranges from 0.5 to 12 MeV. A magnetic quadrupole triplet lens is used to focus the beam of ions. We present the design of this beamline, and early results showing the capability to count single ions with 98% certainty on CR-39 track etch. We also show that the beam targeting accuracy is within 5 μm and selectively target human fibroblasts with a",

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AU - Merchant, M M

AU - Jeynes, JCJ

AU - Grime, GW

AU - Palitsin, V

AU - Tullis, IDC

AU - Barber, P

AU - Vojnovic, B

AU - Webb, RP

AU - Kirkby, Karen

N1 - C133/A/1812, Cancer Research UK, United Kingdom, Medical Research Council, United Kingdom

PY - 2012/9

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AB - The Surrey vertical beam is a new facility for targeted irradiation of cells in medium with singly counted ions. A duo-plasmatron ion source and a 2 MV Tandem™ accelerator supply a range of ions from protons to calcium for this beamline and microscope endstation, with energy ranges from 0.5 to 12 MeV. A magnetic quadrupole triplet lens is used to focus the beam of ions. We present the design of this beamline, and early results showing the capability to count single ions with 98% certainty on CR-39 track etch. We also show that the beam targeting accuracy is within 5 μm and selectively target human fibroblasts with a

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DO - 10.1667/RR2847.1

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VL - 178

JO - Radiation Research

JF - Radiation Research

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A focused scanning vertical beam for charged particle irradiation of living cells with single counted particles.

Abstract

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