A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2

M C Schneider; A M Rodriguez; H Nomura; J Zhou; C C Morton; S T Reeders; S Weremowicz

doi:10.1006/geno.1996.0584

A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2

M C Schneider
, A M Rodriguez
, H Nomura
, J Zhou
, C C Morton
, S T Reeders
, S Weremowicz

Division of Evolution, Infection and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

We report a partial cDNA sequence that encodes a protein, dubbed "polycystwin," with 21% identify and 46% similarity to amino acids 3688-4109 of the carboxyl terminus of polycystin, the gene product of the autosomal dominant polycystic kidney disease locus located on chromosome 16 at band p13 (PKD1). Northern analysis demonstrates that the R48321 gene is expressed in all tissues examined, including both adult and fetal kidneys. Finally, in situ hybridization studies localize this novel gene to 4q22, where PKD2, the second most common locus for ADPKD, is known to map. Therefore, R48321 is an excellent candidate gene for PKD2.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Genomics
Volume	38
Issue number	1
DOIs	https://doi.org/10.1006/geno.1996.0584
Publication status	Published - 15 Nov 1996

Keywords

Amino Acid Sequence
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 4
DNA, Complementary
Humans
In Situ Hybridization
Membrane Proteins
Molecular Sequence Data
Proteins
Sequence Homology, Amino Acid
TRPP Cation Channels
Journal Article
Research Support, U.S. Gov't, P.H.S.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/geno.1996.0584

Cite this

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title = "A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2",

abstract = "We report a partial cDNA sequence that encodes a protein, dubbed {"}polycystwin,{"} with 21\% identify and 46\% similarity to amino acids 3688-4109 of the carboxyl terminus of polycystin, the gene product of the autosomal dominant polycystic kidney disease locus located on chromosome 16 at band p13 (PKD1). Northern analysis demonstrates that the R48321 gene is expressed in all tissues examined, including both adult and fetal kidneys. Finally, in situ hybridization studies localize this novel gene to 4q22, where PKD2, the second most common locus for ADPKD, is known to map. Therefore, R48321 is an excellent candidate gene for PKD2.",

keywords = "Amino Acid Sequence, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 4, DNA, Complementary, Humans, In Situ Hybridization, Membrane Proteins, Molecular Sequence Data, Proteins, Sequence Homology, Amino Acid, TRPP Cation Channels, Journal Article, Research Support, U.S. Gov't, P.H.S.",

author = "Schneider, \{M C\} and Rodriguez, \{A M\} and H Nomura and J Zhou and Morton, \{C C\} and Reeders, \{S T\} and S Weremowicz",

year = "1996",

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day = "15",

doi = "10.1006/geno.1996.0584",

language = "English",

volume = "38",

pages = "1--4",

journal = "Genomics",

issn = "0888-7543",

publisher = "Elsevier BV",

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TY - JOUR

T1 - A gene similar to PKD1 maps to chromosome 4q22

T2 - a candidate gene for PKD2

AU - Schneider, M C

AU - Rodriguez, A M

AU - Nomura, H

AU - Zhou, J

AU - Morton, C C

AU - Reeders, S T

AU - Weremowicz, S

PY - 1996/11/15

Y1 - 1996/11/15

N2 - We report a partial cDNA sequence that encodes a protein, dubbed "polycystwin," with 21% identify and 46% similarity to amino acids 3688-4109 of the carboxyl terminus of polycystin, the gene product of the autosomal dominant polycystic kidney disease locus located on chromosome 16 at band p13 (PKD1). Northern analysis demonstrates that the R48321 gene is expressed in all tissues examined, including both adult and fetal kidneys. Finally, in situ hybridization studies localize this novel gene to 4q22, where PKD2, the second most common locus for ADPKD, is known to map. Therefore, R48321 is an excellent candidate gene for PKD2.

AB - We report a partial cDNA sequence that encodes a protein, dubbed "polycystwin," with 21% identify and 46% similarity to amino acids 3688-4109 of the carboxyl terminus of polycystin, the gene product of the autosomal dominant polycystic kidney disease locus located on chromosome 16 at band p13 (PKD1). Northern analysis demonstrates that the R48321 gene is expressed in all tissues examined, including both adult and fetal kidneys. Finally, in situ hybridization studies localize this novel gene to 4q22, where PKD2, the second most common locus for ADPKD, is known to map. Therefore, R48321 is an excellent candidate gene for PKD2.

KW - Amino Acid Sequence

KW - Base Sequence

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 4

KW - DNA, Complementary

KW - Humans

KW - In Situ Hybridization

KW - Membrane Proteins

KW - Molecular Sequence Data

KW - Proteins

KW - Sequence Homology, Amino Acid

KW - TRPP Cation Channels

KW - Journal Article

KW - Research Support, U.S. Gov't, P.H.S.

U2 - 10.1006/geno.1996.0584

DO - 10.1006/geno.1996.0584

M3 - Article

C2 - 8954772

SN - 0888-7543

VL - 38

SP - 1

EP - 4

JO - Genomics

JF - Genomics

IS - 1

ER -

A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2

Abstract

Keywords

UN SDGs

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