A genome-wide association search for type 2 diabetes genes in african americans

Soumya Raychaudhuri; Nicholette D. Palmer; Caitrin W. McDonough; Pamela J. Hicks; Bong H. Roh; Maria R. Wing; S. Sandy An; Jessica M. Hester; Jessica N. Cooke; Meredith A. Bostrom; Megan E. Rudock; Matthew E. Talbert; Joshua P. Lewis; Assiamira Ferrara; Lingyi Lu; Julie T. Ziegler; Michele M. Sale; Jasmin Divers; Daniel Shriner; Adebowale Adeyemo; Charles N. Rotimi; Maggie C Y Ng; Carl D. Langefeld; Barry I. Freedman; Donald W. Bowden

doi:10.1371/journal.pone.0029202

A genome-wide association search for type 2 diabetes genes in african americans

Soumya Raychaudhuri
, Nicholette D. Palmer
, Caitrin W. McDonough
, Pamela J. Hicks
, Bong H. Roh
, Maria R. Wing
, S. Sandy An
, Jessica M. Hester
, Jessica N. Cooke
, Meredith A. Bostrom
, Megan E. Rudock
, Matthew E. Talbert
, Joshua P. Lewis
, Assiamira Ferrara
, Lingyi Lu
, Julie T. Ziegler
, Michele M. Sale
, Jasmin Divers
, Daniel Shriner
, Adebowale Adeyemo

Charles N. Rotimi, Maggie C Y Ng, Carl D. Langefeld, Barry I. Freedman, Donald W. Bowden

Research output: Contribution to journal › Article › peer-review

Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

Original language	English
Article number	e29202
Journal	PLoS ONE
Volume	7
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0029202
Publication status	Published - 4 Jan 2012

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Raychaudhuri, S., Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., ... Bowden, D. W. (2012). A genome-wide association search for type 2 diabetes genes in african americans. PLoS ONE, 7(1), Article e29202. https://doi.org/10.1371/journal.pone.0029202

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abstract = "African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P",

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Raychaudhuri, S, Palmer, ND, McDonough, CW, Hicks, PJ, Roh, BH, Wing, MR, An, SS, Hester, JM, Cooke, JN, Bostrom, MA, Rudock, ME, Talbert, ME, Lewis, JP, Ferrara, A, Lu, L, Ziegler, JT, Sale, MM, Divers, J, Shriner, D, Adeyemo, A, Rotimi, CN, Ng, MCY, Langefeld, CD, Freedman, BI & Bowden, DW 2012, 'A genome-wide association search for type 2 diabetes genes in african americans', PLoS ONE, vol. 7, no. 1, e29202. https://doi.org/10.1371/journal.pone.0029202

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T1 - A genome-wide association search for type 2 diabetes genes in african americans

AU - Raychaudhuri, Soumya

AU - Palmer, Nicholette D.

AU - McDonough, Caitrin W.

AU - Hicks, Pamela J.

AU - Roh, Bong H.

AU - Wing, Maria R.

AU - An, S. Sandy

AU - Hester, Jessica M.

AU - Cooke, Jessica N.

AU - Bostrom, Meredith A.

AU - Rudock, Megan E.

AU - Talbert, Matthew E.

AU - Lewis, Joshua P.

AU - Ferrara, Assiamira

AU - Lu, Lingyi

AU - Ziegler, Julie T.

AU - Sale, Michele M.

AU - Divers, Jasmin

AU - Shriner, Daniel

AU - Adeyemo, Adebowale

AU - Rotimi, Charles N.

AU - Ng, Maggie C Y

AU - Langefeld, Carl D.

AU - Freedman, Barry I.

AU - Bowden, Donald W.

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DO - 10.1371/journal.pone.0029202

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JO - PLoS ONE

JF - PLoS ONE

IS - 1

M1 - e29202

ER -

A genome-wide association search for type 2 diabetes genes in african americans

Abstract

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