TY - JOUR
T1 - A global call for talaromycosis to be recognised as a neglected tropical disease
AU - Narayanasamy, Shanti
AU - Dat, Vu Quoc
AU - Thanh, Nguyen Tat
AU - Ly, Vo Trieu
AU - Chan, Jasper Fuk-Woo
AU - Yuen, Kwok-Yung
AU - Ning, Chuanyi
AU - Liang, Hao
AU - Li, Linghua
AU - Chowdhary, Anuradha
AU - Youngchim, Sirida
AU - Supparatpinyo, Khuanchai
AU - Aung, Ne Myo
AU - Hanson, Josh
AU - Andrianopoulos, Alex
AU - Dougherty, John
AU - Govender, Nelesh P
AU - Denning, David W
AU - Chiller, Tom
AU - Thwaites, Guy
AU - van Doorn, H Rogier
AU - Perfect, John
AU - Le, Thuy
N1 - Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.
PY - 2021/11
Y1 - 2021/11
N2 - Talaromycosis (penicilliosis) is an invasive mycosis that is endemic in tropical and subtropical Asia. Talaromycosis primarily affects individuals with advanced HIV disease and other immunosuppressive conditions, and the disease disproportionally affects people in low-income and middle-income countries, particularly agricultural workers in rural areas during their most economically productive years. Approximately 17 300 talaromycosis cases and 4900 associated deaths occur annually. Talaromycosis is highly associated with the tropical monsoon season, when flooding and cyclones can exacerbate the poverty-inducing potential of the disease. Talaromycosis can present as localised or disseminated disease, the latter causing cutaneous lesions that are disfiguring and stigmatising. Despite up to a third of diagnosed cases resulting in death, talaromycosis has received little attention and investment from regional and global funders, policy makers, researchers, and industry. Diagnostic and treatment modalities remain extremely insufficient, however control of talaromycosis is feasible with known public health strategies. This Viewpoint is a global call for talaromycosis to be recognised as a neglected tropical disease to alleviate its impact on susceptible populations.
AB - Talaromycosis (penicilliosis) is an invasive mycosis that is endemic in tropical and subtropical Asia. Talaromycosis primarily affects individuals with advanced HIV disease and other immunosuppressive conditions, and the disease disproportionally affects people in low-income and middle-income countries, particularly agricultural workers in rural areas during their most economically productive years. Approximately 17 300 talaromycosis cases and 4900 associated deaths occur annually. Talaromycosis is highly associated with the tropical monsoon season, when flooding and cyclones can exacerbate the poverty-inducing potential of the disease. Talaromycosis can present as localised or disseminated disease, the latter causing cutaneous lesions that are disfiguring and stigmatising. Despite up to a third of diagnosed cases resulting in death, talaromycosis has received little attention and investment from regional and global funders, policy makers, researchers, and industry. Diagnostic and treatment modalities remain extremely insufficient, however control of talaromycosis is feasible with known public health strategies. This Viewpoint is a global call for talaromycosis to be recognised as a neglected tropical disease to alleviate its impact on susceptible populations.
KW - Asia/epidemiology
KW - Humans
KW - Mycoses/classification
KW - Neglected Diseases/classification
KW - Public Health/classification
KW - Tropical Medicine/classification
U2 - 10.1016/S2214-109X(21)00350-8
DO - 10.1016/S2214-109X(21)00350-8
M3 - Review article
C2 - 34678201
SN - 2214-109X
VL - 9
SP - e1618-e1622
JO - The Lancet Global Health
JF - The Lancet Global Health
IS - 11
ER -