A Greek Tragedy: the Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

Robert J. Andrew, Katherine Kellett, Gopal Thinakaran, Nigel Hooper

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Abstract

Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β. However, recent evidence suggests that the accepted view of APP proteolysis by the canonical α-, β-, and γ-secretases is simplistic, with the discovery of a number of novel APP secretases (including δ- and η-secretases, alternative β-secretases) and additional metabolites, some of which may also cause synaptic dysfunction. Furthermore, various proteins have been identified that interact with APP and modulate its cleavage by the secretases. Here, we give an overview of the increasingly complex picture of APP proteolysis.
Original languageEnglish
Pages (from-to)19235-19244
Number of pages10
JournalJournal of Biological Chemistry
Volume291
Early online dateJul 2016
DOIs
Publication statusPublished - 9 Sept 2016

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  • Dementia@Manchester

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