A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer

S Stegeman; E Amankwah; K Klein; T A O'Mara; D Kim; H Y Lin; J Permuth-Wey; T A Sellers; S Srinivasan; R Eeles; D Easton; Z Kote-Jarai; A Amin Al Olama; S Benlloch; K Muir; G G Giles; F Wiklund; H Gronberg; C A Haiman; J Schleutker; B G Nordestgaard; R C Travis; D Neal; P Pharoah; K T Khaw; J L Stanford; W J Blot; S Thibodeau; C Maier; A S Kibel; C Cybulski; L Cannon-Albright; H Brenner; R Kaneva; M R Teixeira; A B Spurdle; J A Clements; J Y Park; J Batra

doi:10.1158/2159-8290.CD-14-1057

A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer

S Stegeman, E Amankwah, K Klein, T A O'Mara, D Kim, H Y Lin, J Permuth-Wey, T A Sellers, S Srinivasan, R Eeles, D Easton, Z Kote-Jarai, A Amin Al Olama, S Benlloch, K Muir, G G Giles, F Wiklund, H Gronberg, C A Haiman, J SchleutkerB G Nordestgaard, R C Travis, D Neal, P Pharoah, K T Khaw, J L Stanford, W J Blot, S Thibodeau, C Maier, A S Kibel, C Cybulski, L Cannon-Albright, H Brenner, R Kaneva, M R Teixeira, A B Spurdle, J A Clements, J Y Park, J Batra

Research output: Contribution to journal › Article › peer-review

Abstract

Prostate cancer is the second most common malignancy among men worldwide. Genome-wide association studies have identified 100 risk variants for prostate cancer, which can explain approximately 33% of the familial risk of the disease. We hypothesized that a comprehensive analysis of genetic variations found within the 3' untranslated region of genes predicted to affect miRNA binding (miRSNP) can identify additional prostate cancer risk variants. We investigated the association between 2,169 miRSNPs and prostate cancer risk in a large-scale analysis of 22,301 cases and 22,320 controls of European ancestry from 23 participating studies. Twenty-two miRSNPs were associated (P

Original language	English
Pages (from-to)	368-79
Number of pages	288
Journal	Cancer Discov
Volume	5
Issue number	4
DOIs	https://doi.org/10.1158/2159-8290.CD-14-1057
Publication status	Published - 2015

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10.1158/2159-8290.CD-14-1057

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Stegeman, S., Amankwah, E., Klein, K., O'Mara, T. A., Kim, D., Lin, H. Y., Permuth-Wey, J., Sellers, T. A., Srinivasan, S., Eeles, R., Easton, D., Kote-Jarai, Z., Amin Al Olama, A., Benlloch, S., Muir, K., Giles, G. G., Wiklund, F., Gronberg, H., Haiman, C. A., ... Batra, J. (2015). A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer. Cancer Discov, 5(4), 368-79. https://doi.org/10.1158/2159-8290.CD-14-1057

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abstract = "Prostate cancer is the second most common malignancy among men worldwide. Genome-wide association studies have identified 100 risk variants for prostate cancer, which can explain approximately 33% of the familial risk of the disease. We hypothesized that a comprehensive analysis of genetic variations found within the 3' untranslated region of genes predicted to affect miRNA binding (miRSNP) can identify additional prostate cancer risk variants. We investigated the association between 2,169 miRSNPs and prostate cancer risk in a large-scale analysis of 22,301 cases and 22,320 controls of European ancestry from 23 participating studies. Twenty-two miRSNPs were associated (P",

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year = "2015",

doi = "10.1158/2159-8290.CD-14-1057",

language = "English",

volume = "5",

pages = "368--79",

journal = "Cancer Discov",

issn = "2159-8290",

publisher = "American Association for Cancer Research",

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Stegeman, S, Amankwah, E, Klein, K, O'Mara, TA, Kim, D, Lin, HY, Permuth-Wey, J, Sellers, TA, Srinivasan, S, Eeles, R, Easton, D, Kote-Jarai, Z, Amin Al Olama, A, Benlloch, S, Muir, K, Giles, GG, Wiklund, F, Gronberg, H, Haiman, CA, Schleutker, J, Nordestgaard, BG, Travis, RC, Neal, D, Pharoah, P, Khaw, KT, Stanford, JL, Blot, WJ, Thibodeau, S, Maier, C, Kibel, AS, Cybulski, C, Cannon-Albright, L, Brenner, H, Kaneva, R, Teixeira, MR, Spurdle, AB, Clements, JA, Park, JY & Batra, J 2015, 'A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer', Cancer Discov, vol. 5, no. 4, pp. 368-79. https://doi.org/10.1158/2159-8290.CD-14-1057

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T1 - A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer

AU - Stegeman, S

AU - Amankwah, E

AU - Klein, K

AU - O'Mara, T A

AU - Kim, D

AU - Lin, H Y

AU - Permuth-Wey, J

AU - Sellers, T A

AU - Srinivasan, S

AU - Eeles, R

AU - Easton, D

AU - Kote-Jarai, Z

AU - Amin Al Olama, A

AU - Benlloch, S

AU - Muir, K

AU - Giles, G G

AU - Wiklund, F

AU - Gronberg, H

AU - Haiman, C A

AU - Schleutker, J

AU - Nordestgaard, B G

AU - Travis, R C

AU - Neal, D

AU - Pharoah, P

AU - Khaw, K T

AU - Stanford, J L

AU - Blot, W J

AU - Thibodeau, S

AU - Maier, C

AU - Kibel, A S

AU - Cybulski, C

AU - Cannon-Albright, L

AU - Brenner, H

AU - Kaneva, R

AU - Teixeira, M R

AU - Spurdle, A B

AU - Clements, J A

AU - Park, J Y

AU - Batra, J

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PY - 2015

Y1 - 2015

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AB - Prostate cancer is the second most common malignancy among men worldwide. Genome-wide association studies have identified 100 risk variants for prostate cancer, which can explain approximately 33% of the familial risk of the disease. We hypothesized that a comprehensive analysis of genetic variations found within the 3' untranslated region of genes predicted to affect miRNA binding (miRSNP) can identify additional prostate cancer risk variants. We investigated the association between 2,169 miRSNPs and prostate cancer risk in a large-scale analysis of 22,301 cases and 22,320 controls of European ancestry from 23 participating studies. Twenty-two miRSNPs were associated (P

U2 - 10.1158/2159-8290.CD-14-1057

DO - 10.1158/2159-8290.CD-14-1057

M3 - Article

SN - 2159-8290

VL - 5

SP - 368

EP - 379

JO - Cancer Discov

JF - Cancer Discov

IS - 4

ER -

A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer

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