A longitudinal three-center study of craniofacial morphology at 6 and 12 years of age in patients with complete bilateral cleft lip and palate

Theodosia Bartzela, Christos Katsaros, Elisabeth Rønning, Sara Rizell, Gunvor Semb, Ewald Bronkhorst, Demetrios Halazonetis, Anne Marie Kuijpers-Jagtman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    In this longitudinal study, the craniofacial morphology and evaluated soft tissue profile changes, at 6 and 12 years of age in patients with complete bilateral cleft lip and palate (CBCLP) were compared. Lateral cephalograms from 148 patients with CBCLP, treated consecutively at three European cleft centers, Gothenburg (nA = 37), Nijmegen (nB = 26), and Oslo (nC = 85), were evaluated. Eighteen hard tissue and ten soft tissue landmarks were digitized. Paired t test, Pearson's correlation coefficients, and multiple regression models were applied for statistical analysis. ANOVA and Tukey-B, as a post hoc test, were used to evaluate the increments and compare centers. Hard and soft tissue data were superimposed using the generalized Procrustes analysis. For Nijmegen, the increments of the variables SNA, ANB, SN-NL, SN-ML, NL-ML, Snss, and Snpg were significantly different than the two other centers (p = 0. 041 to
    Original languageEnglish
    Pages (from-to)1313-1324
    Number of pages11
    JournalClinical Oral Investigations
    Volume16
    Issue number4
    DOIs
    Publication statusPublished - Aug 2012

    Keywords

    • Bilateral cleft lip and palate
    • Cephalometry
    • Craniofacial morphology
    • Intercenter study
    • Treatment outcome

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