A mammalian scaffold complex that selectively mediates MAP kinase activation

A J Whitmarsh; J Cavanagh; C Tournier; J Yasuda; R J Davis

A mammalian scaffold complex that selectively mediates MAP kinase activation

A J Whitmarsh, J Cavanagh, C Tournier, J Yasuda, R J Davis

Research output: Contribution to journal › Article › peer-review

Abstract

The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.

Original language	English
Pages (from-to)	1671-4
Number of pages	4
Journal	Science
Volume	281
Issue number	5383
Publication status	Published - 11 Sept 1998

Keywords

Animals
COS Cells
Calcium-Calmodulin-Dependent Protein Kinases
Carrier Proteins
Cell Line
Cercopithecus aethiops
Enzyme Activation
Interleukin-1
JNK Mitogen-Activated Protein Kinases
MAP Kinase Kinase 7
MAP Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Molecular Sequence Data
Protein Kinases
Protein-Serine-Threonine Kinases
Recombinant Fusion Proteins
Signal Transduction

Cite this

@article{98a9eafa00c0458b8e1849b6a5766538,

title = "A mammalian scaffold complex that selectively mediates MAP kinase activation",

abstract = "The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.",

keywords = "Animals, COS Cells, Calcium-Calmodulin-Dependent Protein Kinases, Carrier Proteins, Cell Line, Cercopithecus aethiops, Enzyme Activation, Interleukin-1, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase 7, MAP Kinase Kinase Kinases, Mitogen-Activated Protein Kinase Kinases, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Protein Kinases, Protein-Serine-Threonine Kinases, Recombinant Fusion Proteins, Signal Transduction",

author = "Whitmarsh, {A J} and J Cavanagh and C Tournier and J Yasuda and Davis, {R J}",

year = "1998",

month = sep,

day = "11",

language = "English",

volume = "281",

pages = "1671--4",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science (A A A S)",

number = "5383",

}

TY - JOUR

T1 - A mammalian scaffold complex that selectively mediates MAP kinase activation

AU - Whitmarsh, A J

AU - Cavanagh, J

AU - Tournier, C

AU - Yasuda, J

AU - Davis, R J

PY - 1998/9/11

Y1 - 1998/9/11

N2 - The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.

AB - The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.

KW - Animals

KW - COS Cells

KW - Calcium-Calmodulin-Dependent Protein Kinases

KW - Carrier Proteins

KW - Cell Line

KW - Cercopithecus aethiops

KW - Enzyme Activation

KW - Interleukin-1

KW - JNK Mitogen-Activated Protein Kinases

KW - MAP Kinase Kinase 7

KW - MAP Kinase Kinase Kinases

KW - Mitogen-Activated Protein Kinase Kinases

KW - Mitogen-Activated Protein Kinases

KW - Molecular Sequence Data

KW - Protein Kinases

KW - Protein-Serine-Threonine Kinases

KW - Recombinant Fusion Proteins

KW - Signal Transduction

M3 - Article

C2 - 9733513

SN - 0036-8075

VL - 281

SP - 1671

EP - 1674

JO - Science

JF - Science

IS - 5383

ER -

A mammalian scaffold complex that selectively mediates MAP kinase activation

Abstract

Keywords

Fingerprint

Cite this