A mathematical model of response of cells to radiation

M. Richard; K. J. Kirkby; R. P. Webb; N. F. Kirkby

doi:10.1016/j.nimb.2006.11.077

A mathematical model of response of cells to radiation

M. Richard, K. J. Kirkby, R. P. Webb, N. F. Kirkby^*

^*Corresponding author for this work

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Unexpected behaviour of cells after low doses of radiation have been recently shown. To investigate possible mechanisms involved in these phenomena, a cellular automaton (CA) model was created. A first CA modelled the diffusion of nutrients and signals in the cellular environment; this CA was coupled to a second one which computed the cell cycle of a population of cells and their reaction to radiation. The survival probabilities to doses below 1 Gy were calculated carefully; the communication between targeted and non-targeted cells was also included. Early results on population growth characteristics were in agreement with data of the literature and the model should help understanding further the cellular response to low doses of radiation.

Original language	English
Pages (from-to)	18-22
Number of pages	5
Journal	Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Volume	255
Issue number	1 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.nimb.2006.11.077
Publication status	Published - Feb 2007

Keywords

Bystander effect
Computer simulation
Low dose hyper radio-sensitivity
X-rays irradiation

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

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10.1016/j.nimb.2006.11.077

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abstract = "Unexpected behaviour of cells after low doses of radiation have been recently shown. To investigate possible mechanisms involved in these phenomena, a cellular automaton (CA) model was created. A first CA modelled the diffusion of nutrients and signals in the cellular environment; this CA was coupled to a second one which computed the cell cycle of a population of cells and their reaction to radiation. The survival probabilities to doses below 1 Gy were calculated carefully; the communication between targeted and non-targeted cells was also included. Early results on population growth characteristics were in agreement with data of the literature and the model should help understanding further the cellular response to low doses of radiation.",

keywords = "Bystander effect, Computer simulation, Low dose hyper radio-sensitivity, X-rays irradiation",

author = "M. Richard and Kirkby, {K. J.} and Webb, {R. P.} and Kirkby, {N. F.}",

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AU - Webb, R. P.

AU - Kirkby, N. F.

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N2 - Unexpected behaviour of cells after low doses of radiation have been recently shown. To investigate possible mechanisms involved in these phenomena, a cellular automaton (CA) model was created. A first CA modelled the diffusion of nutrients and signals in the cellular environment; this CA was coupled to a second one which computed the cell cycle of a population of cells and their reaction to radiation. The survival probabilities to doses below 1 Gy were calculated carefully; the communication between targeted and non-targeted cells was also included. Early results on population growth characteristics were in agreement with data of the literature and the model should help understanding further the cellular response to low doses of radiation.

AB - Unexpected behaviour of cells after low doses of radiation have been recently shown. To investigate possible mechanisms involved in these phenomena, a cellular automaton (CA) model was created. A first CA modelled the diffusion of nutrients and signals in the cellular environment; this CA was coupled to a second one which computed the cell cycle of a population of cells and their reaction to radiation. The survival probabilities to doses below 1 Gy were calculated carefully; the communication between targeted and non-targeted cells was also included. Early results on population growth characteristics were in agreement with data of the literature and the model should help understanding further the cellular response to low doses of radiation.

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KW - Computer simulation

KW - Low dose hyper radio-sensitivity

KW - X-rays irradiation

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JF - Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

IS - 1 SPEC. ISS.

ER -

A mathematical model of response of cells to radiation

Abstract

Keywords

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