A matter of time: study of circadian clocks and their role in inflammation.

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    Circadian rhythms regulate changes in physiology, allowing organisms to respond to predictable environmental demands varying over a 24 h period. A growing body of evidence supports a key role for the circadian clock in the regulation of immune functions and inflammatory responses, which influence the understanding of infections and inflammatory diseases and their treatment. A variety of experimental methods have been used to assess the complex bidirectional crosstalk between the circadian clock and inflammation. In this review, we summarize the organization of the molecular clock, experimental methods used to study circadian rhythms, and both the inflammatory and immune consequences of circadian disturbance.
    Original languageEnglish
    Pages (from-to)549-560
    Number of pages12
    JournalJournal of leukocyte biology|J Leukoc Biol
    Issue number4
    Early online date8 Feb 2016
    Publication statusPublished - Apr 2016


    • entrainment
    • immunity
    • jet lag
    • knockout
    • synchronization


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