A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

A A Al Olama; Z Kote-Jarai; S I Berndt; D V Conti; F Schumacher; Y Han; S Benlloch; D J Hazelett; Z Wang; E Saunders; D Leongamornlert; S Lindstrom; S Jugurnauth-Little; T Dadaev; M Tymrakiewicz; D O Stram; K Rand; P Wan; A Stram; X Sheng; L C Pooler; K Park; L Xia; J Tyrer; L N Kolonel; L Le Marchand; R N Hoover; M J Machiela; M Yeager; L Burdette; C C Chung; A Hutchinson; K Yu; C Goh; M Ahmed; K Govindasami; M Guy; T L Tammela; A Auvinen; T Wahlfors; J Schleutker; T Visakorpi; K A Leinonen; J Xu; M Aly; J Donovan; R C Travis; T J Key; A Siddiq; F Canzian; K T Khaw; A Takahashi; M Kubo; P Pharoah; N Pashayan; M Weischer; B G Nordestgaard; S F Nielsen; P Klarskov; M A Roder; P Iversen; S N Thibodeau; S K McDonnell; D J Schaid; J L Stanford; S Kolb; S Holt; B Knudsen; A H Coll; S M Gapstur; W R Diver; V L Stevens; C Maier; M Luedeke; K Herkommer; A E Rinckleb; S S Strom; C Pettaway; E D Yeboah; Y Tettey; R B Biritwum; A A Adjei; E Tay; A Truelove; S Niwa; A P Chokkalingam; L Cannon-Albright; C Cybulski; D Wokolorczyk; W Kluzniak; J Park; T Sellers; H Y Lin; W B Isaacs; A W Partin; H Brenner; A K Dieffenbach; C Stegmaier; C Chen; E L Giovannucci; J Ma; M Stampfer; K L Penney; L Mucci; E M John; S A Ingles; R A Kittles; A B Murphy; H Pandha; A Michael; A M Kierzek; W Blot; L B Signorello; W Zheng; D Albanes; J Virtamo; S Weinstein; B Nemesure; J Carpten; C Leske; S Y Wu; A Hennis; A S Kibel; B A Rybicki; C Neslund-Dudas; A W Hsing; L Chu; P J Goodman; E A Klein; S L Zheng; J Batra; J Clements; A Spurdle; M R Teixeira; P Paulo; S Maia; C Slavov; R Kaneva; V Mitev; J S Witte; G Casey; E M Gillanders; D Seminara; E Riboli; F C Hamdy; G A Coetzee; Q Li; M L Freedman; D J Hunter; K Muir; H Gronberg; D E Neal; M Southey; G G Giles; G Severi; M B Cook; H Nakagawa; F Wiklund; P Kraft; S J Chanock; B E Henderson; D F Easton; R A Eeles; C A Haiman

doi:10.1038/ng.3094

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

A A Al Olama, Z Kote-Jarai, S I Berndt, D V Conti, F Schumacher, Y Han, S Benlloch, D J Hazelett, Z Wang, E Saunders, D Leongamornlert, S Lindstrom, S Jugurnauth-Little, T Dadaev, M Tymrakiewicz, D O Stram, K Rand, P Wan, A Stram, X ShengL C Pooler, K Park, L Xia, J Tyrer, L N Kolonel, L Le Marchand, R N Hoover, M J Machiela, M Yeager, L Burdette, C C Chung, A Hutchinson, K Yu, C Goh, M Ahmed, K Govindasami, M Guy, T L Tammela, A Auvinen, T Wahlfors, J Schleutker, T Visakorpi, K A Leinonen, J Xu, M Aly, J Donovan, R C Travis, T J Key, A Siddiq, F Canzian, K T Khaw, A Takahashi, M Kubo, P Pharoah, N Pashayan, M Weischer, B G Nordestgaard, S F Nielsen, P Klarskov, M A Roder, P Iversen, S N Thibodeau, S K McDonnell, D J Schaid, J L Stanford, S Kolb, S Holt, B Knudsen, A H Coll, S M Gapstur, W R Diver, V L Stevens, C Maier, M Luedeke, K Herkommer, A E Rinckleb, S S Strom, C Pettaway, E D Yeboah, Y Tettey, R B Biritwum, A A Adjei, E Tay, A Truelove, S Niwa, A P Chokkalingam, L Cannon-Albright, C Cybulski, D Wokolorczyk, W Kluzniak, J Park, T Sellers, H Y Lin, W B Isaacs, A W Partin, H Brenner, A K Dieffenbach, C Stegmaier, C Chen, E L Giovannucci, J Ma, M Stampfer, K L Penney, L Mucci, E M John, S A Ingles, R A Kittles, A B Murphy, H Pandha, A Michael, A M Kierzek, W Blot, L B Signorello, W Zheng, D Albanes, J Virtamo, S Weinstein, B Nemesure, J Carpten, C Leske, S Y Wu, A Hennis, A S Kibel, B A Rybicki, C Neslund-Dudas, A W Hsing, L Chu, P J Goodman, E A Klein, S L Zheng, J Batra, J Clements, A Spurdle, M R Teixeira, P Paulo, S Maia, C Slavov, R Kaneva, V Mitev, J S Witte, G Casey, E M Gillanders, D Seminara, E Riboli, F C Hamdy, G A Coetzee, Q Li, M L Freedman, D J Hunter, K Muir, H Gronberg, D E Neal, M Southey, G G Giles, G Severi, M B Cook, H Nakagawa, F Wiklund, P Kraft, S J Chanock, B E Henderson, D F Easton, R A Eeles, C A Haiman

Research output: Contribution to journal › Article › peer-review

Abstract

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P <5 x 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

Original language	English
Pages (from-to)	1103-9
Number of pages	1093
Journal	Nat Genet
Volume	46
Issue number	10
DOIs	https://doi.org/10.1038/ng.3094
Publication status	Published - 14 Sept 2014

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Cite this

Al Olama, A. A., Kote-Jarai, Z., Berndt, S. I., Conti, D. V., Schumacher, F., Han, Y., Benlloch, S., Hazelett, D. J., Wang, Z., Saunders, E., Leongamornlert, D., Lindstrom, S., Jugurnauth-Little, S., Dadaev, T., Tymrakiewicz, M., Stram, D. O., Rand, K., Wan, P., Stram, A., ... Haiman, C. A. (2014). A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat Genet, 46(10), 1103-9. https://doi.org/10.1038/ng.3094

@article{0577ad83f1264666aad874a4c4fd7aed,

title = "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer",

abstract = "Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P <5 x 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.",

author = "{Al Olama}, {A A} and Z Kote-Jarai and Berndt, {S I} and Conti, {D V} and F Schumacher and Y Han and S Benlloch and Hazelett, {D J} and Z Wang and E Saunders and D Leongamornlert and S Lindstrom and S Jugurnauth-Little and T Dadaev and M Tymrakiewicz and Stram, {D O} and K Rand and P Wan and A Stram and X Sheng and Pooler, {L C} and K Park and L Xia and J Tyrer and Kolonel, {L N} and {Le Marchand}, L and Hoover, {R N} and Machiela, {M J} and M Yeager and L Burdette and Chung, {C C} and A Hutchinson and K Yu and C Goh and M Ahmed and K Govindasami and M Guy and Tammela, {T L} and A Auvinen and T Wahlfors and J Schleutker and T Visakorpi and Leinonen, {K A} and J Xu and M Aly and J Donovan and Travis, {R C} and Key, {T J} and A Siddiq and F Canzian and Khaw, {K T} and A Takahashi and M Kubo and P Pharoah and N Pashayan and M Weischer and Nordestgaard, {B G} and Nielsen, {S F} and P Klarskov and Roder, {M A} and P Iversen and Thibodeau, {S N} and McDonnell, {S K} and Schaid, {D J} and Stanford, {J L} and S Kolb and S Holt and B Knudsen and Coll, {A H} and Gapstur, {S M} and Diver, {W R} and Stevens, {V L} and C Maier and M Luedeke and K Herkommer and Rinckleb, {A E} and Strom, {S S} and C Pettaway and Yeboah, {E D} and Y Tettey and Biritwum, {R B} and Adjei, {A A} and E Tay and A Truelove and S Niwa and Chokkalingam, {A P} and L Cannon-Albright and C Cybulski and D Wokolorczyk and W Kluzniak and J Park and T Sellers and Lin, {H Y} and Isaacs, {W B} and Partin, {A W} and H Brenner and Dieffenbach, {A K} and C Stegmaier and C Chen and Giovannucci, {E L} and J Ma and M Stampfer and Penney, {K L} and L Mucci and John, {E M} and Ingles, {S A} and Kittles, {R A} and Murphy, {A B} and H Pandha and A Michael and Kierzek, {A M} and W Blot and Signorello, {L B} and W Zheng and D Albanes and J Virtamo and S Weinstein and B Nemesure and J Carpten and C Leske and Wu, {S Y} and A Hennis and Kibel, {A S} and Rybicki, {B A} and C Neslund-Dudas and Hsing, {A W} and L Chu and Goodman, {P J} and Klein, {E A} and Zheng, {S L} and J Batra and J Clements and A Spurdle and Teixeira, {M R} and P Paulo and S Maia and C Slavov and R Kaneva and V Mitev and Witte, {J S} and G Casey and Gillanders, {E M} and D Seminara and E Riboli and Hamdy, {F C} and Coetzee, {G A} and Q Li and Freedman, {M L} and Hunter, {D J} and K Muir and H Gronberg and Neal, {D E} and M Southey and Giles, {G G} and G Severi and Cook, {M B} and H Nakagawa and F Wiklund and P Kraft and Chanock, {S J} and Henderson, {B E} and Easton, {D F} and Eeles, {R A} and Haiman, {C A}",

note = "Al Olama, Ali Amin Kote-Jarai, Zsofia Berndt, Sonja I Conti, David V Schumacher, Fredrick Han, Ying Benlloch, Sara Hazelett, Dennis J Wang, Zhaoming Saunders, Ed Leongamornlert, Daniel Lindstrom, Sara Jugurnauth-Little, Sara Dadaev, Tokhir Tymrakiewicz, Malgorzata Stram, Daniel O Rand, Kristin Wan, Peggy Stram, Alex Sheng, Xin Pooler, Loreall C Park, Karen Xia, Lucy Tyrer, Jonathan Kolonel, Laurence N Le Marchand, Loic Hoover, Robert N Machiela, Mitchell J Yeager, Merideth Burdette, Laurie Chung, Charles C Hutchinson, Amy Yu, Kai Goh, Chee Ahmed, Mahbubl Govindasami, Koveela Guy, Michelle Tammela, Teuvo L J Auvinen, Anssi Wahlfors, Tiina Schleutker, Johanna Visakorpi, Tapio Leinonen, Katri A Xu, Jianfeng Aly, Markus Donovan, Jenny Travis, Ruth C Key, Tim J Siddiq, Afshan Canzian, Federico Khaw, Kay-Tee Takahashi, Atsushi Kubo, Michiaki Pharoah, Paul Pashayan, Nora Weischer, Maren Nordestgaard, Borge G Nielsen, Sune F Klarskov, Peter Roder, Martin Andreas Iversen, Peter Thibodeau, Stephen N McDonnell, Shannon K Schaid, Daniel J Stanford, Janet L Kolb, Suzanne Holt, Sarah Knudsen, Beatrice Coll, Antonio Hurtado Gapstur, Susan M Diver, W Ryan Stevens, Victoria L Maier, Christiane Luedeke, Manuel Herkommer, Kathleen Rinckleb, Antje E Strom, Sara S Pettaway, Curtis Yeboah, Edward D Tettey, Yao Biritwum, Richard B Adjei, Andrew A Tay, Evelyn Truelove, Ann Niwa, Shelley Chokkalingam, Anand P Cannon-Albright, Lisa Cybulski, Cezary Wokolorczyk, Dominika Kluzniak, Wojciech Park, Jong Sellers, Thomas Lin, Hui-Yi Isaacs, William B Partin, Alan W Brenner, Hermann Dieffenbach, Aida Karina Stegmaier, Christa Chen, Constance Giovannucci, Edward L Ma, Jing Stampfer, Meir Penney, Kathryn L Mucci, Lorelei John, Esther M Ingles, Sue A Kittles, Rick A Murphy, Adam B Pandha, Hardev Michael, Agnieszka Kierzek, Andrzej M Blot, William Signorello, Lisa B Zheng, Wei Albanes, Demetrius Virtamo, Jarmo Weinstein, Stephanie Nemesure, Barbara Carpten, John Leske, Cristina Wu, Suh-Yuh Hennis, Anselm Kibel, Adam S Rybicki, Benjamin A Neslund-Dudas, Christine Hsing, Ann W Chu, Lisa Goodman, Phyllis J Klein, Eric A Zheng, S Lilly Batra, Jyotsna Clements, Judith Spurdle, Amanda Teixeira, Manuel R Paulo, Paula Maia, Sofia Slavov, Chavdar Kaneva, Radka Mitev, Vanio Witte, John S Casey, Graham Gillanders, Elizabeth M Seminara, Daniella Riboli, Elio Hamdy, Freddie C Coetzee, Gerhard A Li, Qiyuan Freedman, Matthew L Hunter, David J Muir, Kenneth Gronberg, Henrik Neal, David E Southey, Melissa Giles, Graham G Severi, Gianluca Breast and Prostate Cancer Cohort Consortium (BPC3) PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium COGS (Collaborative Oncological Gene-environment Study) Consortium GAME-ON/ELLIPSE Consortium Cook, Michael B Nakagawa, Hidewaki Wiklund, Fredrik Kraft, Peter Chanock, Stephen J Henderson, Brian E Easton, Douglas F Eeles, Rosalind A Haiman, Christopher A 16561/Cancer Research UK/United Kingdom G1000143/Medical Research Council/United Kingdom P30 CA042014/CA/NCI NIH HHS/United States P30 CA068485/CA/NCI NIH HHS/United States P30 ES007784/ES/NIEHS NIH HHS/United States P50 CA140388/CA/NCI NIH HHS/United States R01 CA056678/CA/NCI NIH HHS/United States R01 CA068578/CA/NCI NIH HHS/United States R01 CA072818/CA/NCI NIH HHS/United States R01 CA082664/CA/NCI NIH HHS/United States R01 CA092579/CA/NCI NIH HHS/United States R01 CA128813/CA/NCI NIH HHS/United States R01 CA128978/CA/NCI NIH HHS/United States R01 CA136924/CA/NCI NIH HHS/United States R01 ES011126/ES/NIEHS NIH HHS/United States R37 CA054281/CA/NCI NIH HHS/United States RC2 CA148085/CA/NCI NIH HHS/United States U01 CA063464/CA/NCI NIH HHS/United States U01 CA089600/CA/NCI NIH HHS/United States U01 CA098233/CA/NCI NIH HHS/United States U01 CA098758/CA/NCI NIH HHS/United States U01 CA127298/CA/NCI NIH HHS/United States U01 CA136792/CA/NCI NIH HHS/United States U01 HG004446/HG/NHGRI NIH HHS/United States U01 HG004726/HG/NHGRI NIH HHS/United States U19 CA148112/CA/NCI NIH HHS/United States U19 CA148537/CA/NCI NIH HHS/United States United States Nature genetics Nat Genet. 2014 Oct;46(10):1103-9. doi: 10.1038/ng.3094. Epub 2014 Sep 14.",

year = "2014",

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day = "14",

doi = "10.1038/ng.3094",

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Al Olama, AA, Kote-Jarai, Z, Berndt, SI, Conti, DV, Schumacher, F, Han, Y, Benlloch, S, Hazelett, DJ, Wang, Z, Saunders, E, Leongamornlert, D, Lindstrom, S, Jugurnauth-Little, S, Dadaev, T, Tymrakiewicz, M, Stram, DO, Rand, K, Wan, P, Stram, A, Sheng, X, Pooler, LC, Park, K, Xia, L, Tyrer, J, Kolonel, LN, Le Marchand, L, Hoover, RN, Machiela, MJ, Yeager, M, Burdette, L, Chung, CC, Hutchinson, A, Yu, K, Goh, C, Ahmed, M, Govindasami, K, Guy, M, Tammela, TL, Auvinen, A, Wahlfors, T, Schleutker, J, Visakorpi, T, Leinonen, KA, Xu, J, Aly, M, Donovan, J, Travis, RC, Key, TJ, Siddiq, A, Canzian, F, Khaw, KT, Takahashi, A, Kubo, M, Pharoah, P, Pashayan, N, Weischer, M, Nordestgaard, BG, Nielsen, SF, Klarskov, P, Roder, MA, Iversen, P, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Stanford, JL, Kolb, S, Holt, S, Knudsen, B, Coll, AH, Gapstur, SM, Diver, WR, Stevens, VL, Maier, C, Luedeke, M, Herkommer, K, Rinckleb, AE, Strom, SS, Pettaway, C, Yeboah, ED, Tettey, Y, Biritwum, RB, Adjei, AA, Tay, E, Truelove, A, Niwa, S, Chokkalingam, AP, Cannon-Albright, L, Cybulski, C, Wokolorczyk, D, Kluzniak, W, Park, J, Sellers, T, Lin, HY, Isaacs, WB, Partin, AW, Brenner, H, Dieffenbach, AK, Stegmaier, C, Chen, C, Giovannucci, EL, Ma, J, Stampfer, M, Penney, KL, Mucci, L, John, EM, Ingles, SA, Kittles, RA, Murphy, AB, Pandha, H, Michael, A, Kierzek, AM, Blot, W, Signorello, LB, Zheng, W, Albanes, D, Virtamo, J, Weinstein, S, Nemesure, B, Carpten, J, Leske, C, Wu, SY, Hennis, A, Kibel, AS, Rybicki, BA, Neslund-Dudas, C, Hsing, AW, Chu, L, Goodman, PJ, Klein, EA, Zheng, SL, Batra, J, Clements, J, Spurdle, A, Teixeira, MR, Paulo, P, Maia, S, Slavov, C, Kaneva, R, Mitev, V, Witte, JS, Casey, G, Gillanders, EM, Seminara, D, Riboli, E, Hamdy, FC, Coetzee, GA, Li, Q, Freedman, ML, Hunter, DJ, Muir, K, Gronberg, H, Neal, DE, Southey, M, Giles, GG, Severi, G, Cook, MB, Nakagawa, H, Wiklund, F, Kraft, P, Chanock, SJ, Henderson, BE, Easton, DF, Eeles, RA & Haiman, CA 2014, 'A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer', Nat Genet, vol. 46, no. 10, pp. 1103-9. https://doi.org/10.1038/ng.3094

TY - JOUR

T1 - A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

AU - Al Olama, A A

AU - Kote-Jarai, Z

AU - Berndt, S I

AU - Conti, D V

AU - Schumacher, F

AU - Han, Y

AU - Benlloch, S

AU - Hazelett, D J

AU - Wang, Z

AU - Saunders, E

AU - Leongamornlert, D

AU - Lindstrom, S

AU - Jugurnauth-Little, S

AU - Dadaev, T

AU - Tymrakiewicz, M

AU - Stram, D O

AU - Rand, K

AU - Wan, P

AU - Stram, A

AU - Sheng, X

AU - Pooler, L C

AU - Park, K

AU - Xia, L

AU - Tyrer, J

AU - Kolonel, L N

AU - Le Marchand, L

AU - Hoover, R N

AU - Machiela, M J

AU - Yeager, M

AU - Burdette, L

AU - Chung, C C

AU - Hutchinson, A

AU - Yu, K

AU - Goh, C

AU - Ahmed, M

AU - Govindasami, K

AU - Guy, M

AU - Tammela, T L

AU - Auvinen, A

AU - Wahlfors, T

AU - Schleutker, J

AU - Visakorpi, T

AU - Leinonen, K A

AU - Xu, J

AU - Aly, M

AU - Donovan, J

AU - Travis, R C

AU - Key, T J

AU - Siddiq, A

AU - Canzian, F

AU - Khaw, K T

AU - Takahashi, A

AU - Kubo, M

AU - Pharoah, P

AU - Pashayan, N

AU - Weischer, M

AU - Nordestgaard, B G

AU - Nielsen, S F

AU - Klarskov, P

AU - Roder, M A

AU - Iversen, P

AU - Thibodeau, S N

AU - McDonnell, S K

AU - Schaid, D J

AU - Stanford, J L

AU - Kolb, S

AU - Holt, S

AU - Knudsen, B

AU - Coll, A H

AU - Gapstur, S M

AU - Diver, W R

AU - Stevens, V L

AU - Maier, C

AU - Luedeke, M

AU - Herkommer, K

AU - Rinckleb, A E

AU - Strom, S S

AU - Pettaway, C

AU - Yeboah, E D

AU - Tettey, Y

AU - Biritwum, R B

AU - Adjei, A A

AU - Tay, E

AU - Truelove, A

AU - Niwa, S

AU - Chokkalingam, A P

AU - Cannon-Albright, L

AU - Cybulski, C

AU - Wokolorczyk, D

AU - Kluzniak, W

AU - Park, J

AU - Sellers, T

AU - Lin, H Y

AU - Isaacs, W B

AU - Partin, A W

AU - Brenner, H

AU - Dieffenbach, A K

AU - Stegmaier, C

AU - Chen, C

AU - Giovannucci, E L

AU - Ma, J

AU - Stampfer, M

AU - Penney, K L

AU - Mucci, L

AU - John, E M

AU - Ingles, S A

AU - Kittles, R A

AU - Murphy, A B

AU - Pandha, H

AU - Michael, A

AU - Kierzek, A M

AU - Blot, W

AU - Signorello, L B

AU - Zheng, W

AU - Albanes, D

AU - Virtamo, J

AU - Weinstein, S

AU - Nemesure, B

AU - Carpten, J

AU - Leske, C

AU - Wu, S Y

AU - Hennis, A

AU - Kibel, A S

AU - Rybicki, B A

AU - Neslund-Dudas, C

AU - Hsing, A W

AU - Chu, L

AU - Goodman, P J

AU - Klein, E A

AU - Zheng, S L

AU - Batra, J

AU - Clements, J

AU - Spurdle, A

AU - Teixeira, M R

AU - Paulo, P

AU - Maia, S

AU - Slavov, C

AU - Kaneva, R

AU - Mitev, V

AU - Witte, J S

AU - Casey, G

AU - Gillanders, E M

AU - Seminara, D

AU - Riboli, E

AU - Hamdy, F C

AU - Coetzee, G A

AU - Li, Q

AU - Freedman, M L

AU - Hunter, D J

AU - Muir, K

AU - Gronberg, H

AU - Neal, D E

AU - Southey, M

AU - Giles, G G

AU - Severi, G

AU - Cook, M B

AU - Nakagawa, H

AU - Wiklund, F

AU - Kraft, P

AU - Chanock, S J

AU - Henderson, B E

AU - Easton, D F

AU - Eeles, R A

AU - Haiman, C A

N1 - Al Olama, Ali Amin Kote-Jarai, Zsofia Berndt, Sonja I Conti, David V Schumacher, Fredrick Han, Ying Benlloch, Sara Hazelett, Dennis J Wang, Zhaoming Saunders, Ed Leongamornlert, Daniel Lindstrom, Sara Jugurnauth-Little, Sara Dadaev, Tokhir Tymrakiewicz, Malgorzata Stram, Daniel O Rand, Kristin Wan, Peggy Stram, Alex Sheng, Xin Pooler, Loreall C Park, Karen Xia, Lucy Tyrer, Jonathan Kolonel, Laurence N Le Marchand, Loic Hoover, Robert N Machiela, Mitchell J Yeager, Merideth Burdette, Laurie Chung, Charles C Hutchinson, Amy Yu, Kai Goh, Chee Ahmed, Mahbubl Govindasami, Koveela Guy, Michelle Tammela, Teuvo L J Auvinen, Anssi Wahlfors, Tiina Schleutker, Johanna Visakorpi, Tapio Leinonen, Katri A Xu, Jianfeng Aly, Markus Donovan, Jenny Travis, Ruth C Key, Tim J Siddiq, Afshan Canzian, Federico Khaw, Kay-Tee Takahashi, Atsushi Kubo, Michiaki Pharoah, Paul Pashayan, Nora Weischer, Maren Nordestgaard, Borge G Nielsen, Sune F Klarskov, Peter Roder, Martin Andreas Iversen, Peter Thibodeau, Stephen N McDonnell, Shannon K Schaid, Daniel J Stanford, Janet L Kolb, Suzanne Holt, Sarah Knudsen, Beatrice Coll, Antonio Hurtado Gapstur, Susan M Diver, W Ryan Stevens, Victoria L Maier, Christiane Luedeke, Manuel Herkommer, Kathleen Rinckleb, Antje E Strom, Sara S Pettaway, Curtis Yeboah, Edward D Tettey, Yao Biritwum, Richard B Adjei, Andrew A Tay, Evelyn Truelove, Ann Niwa, Shelley Chokkalingam, Anand P Cannon-Albright, Lisa Cybulski, Cezary Wokolorczyk, Dominika Kluzniak, Wojciech Park, Jong Sellers, Thomas Lin, Hui-Yi Isaacs, William B Partin, Alan W Brenner, Hermann Dieffenbach, Aida Karina Stegmaier, Christa Chen, Constance Giovannucci, Edward L Ma, Jing Stampfer, Meir Penney, Kathryn L Mucci, Lorelei John, Esther M Ingles, Sue A Kittles, Rick A Murphy, Adam B Pandha, Hardev Michael, Agnieszka Kierzek, Andrzej M Blot, William Signorello, Lisa B Zheng, Wei Albanes, Demetrius Virtamo, Jarmo Weinstein, Stephanie Nemesure, Barbara Carpten, John Leske, Cristina Wu, Suh-Yuh Hennis, Anselm Kibel, Adam S Rybicki, Benjamin A Neslund-Dudas, Christine Hsing, Ann W Chu, Lisa Goodman, Phyllis J Klein, Eric A Zheng, S Lilly Batra, Jyotsna Clements, Judith Spurdle, Amanda Teixeira, Manuel R Paulo, Paula Maia, Sofia Slavov, Chavdar Kaneva, Radka Mitev, Vanio Witte, John S Casey, Graham Gillanders, Elizabeth M Seminara, Daniella Riboli, Elio Hamdy, Freddie C Coetzee, Gerhard A Li, Qiyuan Freedman, Matthew L Hunter, David J Muir, Kenneth Gronberg, Henrik Neal, David E Southey, Melissa Giles, Graham G Severi, Gianluca Breast and Prostate Cancer Cohort Consortium (BPC3) PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium COGS (Collaborative Oncological Gene-environment Study) Consortium GAME-ON/ELLIPSE Consortium Cook, Michael B Nakagawa, Hidewaki Wiklund, Fredrik Kraft, Peter Chanock, Stephen J Henderson, Brian E Easton, Douglas F Eeles, Rosalind A Haiman, Christopher A 16561/Cancer Research UK/United Kingdom G1000143/Medical Research Council/United Kingdom P30 CA042014/CA/NCI NIH HHS/United States P30 CA068485/CA/NCI NIH HHS/United States P30 ES007784/ES/NIEHS NIH HHS/United States P50 CA140388/CA/NCI NIH HHS/United States R01 CA056678/CA/NCI NIH HHS/United States R01 CA068578/CA/NCI NIH HHS/United States R01 CA072818/CA/NCI NIH HHS/United States R01 CA082664/CA/NCI NIH HHS/United States R01 CA092579/CA/NCI NIH HHS/United States R01 CA128813/CA/NCI NIH HHS/United States R01 CA128978/CA/NCI NIH HHS/United States R01 CA136924/CA/NCI NIH HHS/United States R01 ES011126/ES/NIEHS NIH HHS/United States R37 CA054281/CA/NCI NIH HHS/United States RC2 CA148085/CA/NCI NIH HHS/United States U01 CA063464/CA/NCI NIH HHS/United States U01 CA089600/CA/NCI NIH HHS/United States U01 CA098233/CA/NCI NIH HHS/United States U01 CA098758/CA/NCI NIH HHS/United States U01 CA127298/CA/NCI NIH HHS/United States U01 CA136792/CA/NCI NIH HHS/United States U01 HG004446/HG/NHGRI NIH HHS/United States U01 HG004726/HG/NHGRI NIH HHS/United States U19 CA148112/CA/NCI NIH HHS/United States U19 CA148537/CA/NCI NIH HHS/United States United States Nature genetics Nat Genet. 2014 Oct;46(10):1103-9. doi: 10.1038/ng.3094. Epub 2014 Sep 14.

PY - 2014/9/14

Y1 - 2014/9/14

N2 - Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P <5 x 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

AB - Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P <5 x 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

U2 - 10.1038/ng.3094

DO - 10.1038/ng.3094

M3 - Article

SN - 1546-1718

VL - 46

SP - 1103

EP - 1109

JO - Nat Genet

JF - Nat Genet

IS - 10

ER -

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

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