A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

Buhm Han; Jennie G.  Pouget; Kamil Slowikowski; Eli Stahl; Cue Hyunkyu Lee; Dorothée Diogo; Xinli Hu; Yu Rang Park; Eunji Kim; Peter K Gregersen; Solbritt Rantapää Dahlqvist; Jane Worthington; Javier Martin; Stephen Eyre; Lars Klareskog; Tom Huizinga; Wei-Min Chen; Suna Onengut-Gumuscu; Stephen S Rich; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Naomi R Wray; Soumya Raychaudhuri

doi:10.1038/ng.3572

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

Buhm Han, Jennie G. Pouget, Kamil Slowikowski, Eli Stahl, Cue Hyunkyu Lee, Dorothée Diogo, Xinli Hu, Yu Rang Park, Eunji Kim, Peter K Gregersen, Solbritt Rantapää Dahlqvist, Jane Worthington, Javier Martin, Stephen Eyre, Lars Klareskog, Tom Huizinga, Wei-Min Chen, Suna Onengut-Gumuscu, Stephen S Rich, Major Depressive Disorder Working Group of the Psychiatric Genomics ConsortiumNaomi R Wray, Soumya Raychaudhuri

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Original language	English
Pages (from-to)	803 - 810
Journal	Nature Genetics
Volume	48
Issue number	7
Early online date	16 May 2016
DOIs	https://doi.org/10.1038/ng.3572
Publication status	Published - 2016

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Nature Genetics 2016 Han-1Accepted author manuscript, 1.06 MB

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Han, B., Pouget, J. G., Slowikowski, K., Stahl, E., Lee, C. H., Diogo, D., Hu, X., Park, Y. R., Kim, E., Gregersen, P. K., Dahlqvist, S. R., Worthington, J., Martin, J., Eyre, S., Klareskog, L., Huizinga, T., Chen, W.-M., Onengut-Gumuscu, S., Rich, S. S., ... Raychaudhuri, S. (2016). A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nature Genetics, 48(7), 803 - 810. https://doi.org/10.1038/ng.3572

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title = "A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases",

author = "Buhm Han and Pouget, {Jennie G.} and Kamil Slowikowski and Eli Stahl and Lee, {Cue Hyunkyu} and Doroth{\'e}e Diogo and Xinli Hu and Park, {Yu Rang} and Eunji Kim and Gregersen, {Peter K} and Dahlqvist, {Solbritt Rantap{\"a}{\"a}} and Jane Worthington and Javier Martin and Stephen Eyre and Lars Klareskog and Tom Huizinga and Wei-Min Chen and Suna Onengut-Gumuscu and Rich, {Stephen S} and {Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium} and Wray, {Naomi R} and Soumya Raychaudhuri",

year = "2016",

doi = "10.1038/ng.3572",

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volume = "48",

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Han, B, Pouget, JG, Slowikowski, K, Stahl, E, Lee, CH, Diogo, D, Hu, X, Park, YR, Kim, E, Gregersen, PK, Dahlqvist, SR, Worthington, J, Martin, J, Eyre, S, Klareskog, L, Huizinga, T, Chen, W-M, Onengut-Gumuscu, S, Rich, SS, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, NR & Raychaudhuri, S 2016, 'A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases', Nature Genetics, vol. 48, no. 7, pp. 803 - 810. https://doi.org/10.1038/ng.3572

TY - JOUR

T1 - A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

AU - Han, Buhm

AU - Pouget, Jennie G.

AU - Slowikowski, Kamil

AU - Stahl, Eli

AU - Lee, Cue Hyunkyu

AU - Diogo, Dorothée

AU - Hu, Xinli

AU - Park, Yu Rang

AU - Kim, Eunji

AU - Gregersen, Peter K

AU - Dahlqvist, Solbritt Rantapää

AU - Worthington, Jane

AU - Martin, Javier

AU - Eyre, Stephen

AU - Klareskog, Lars

AU - Huizinga, Tom

AU - Chen, Wei-Min

AU - Onengut-Gumuscu, Suna

AU - Rich, Stephen S

AU - Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

AU - Wray, Naomi R

AU - Raychaudhuri, Soumya

PY - 2016

Y1 - 2016

U2 - 10.1038/ng.3572

DO - 10.1038/ng.3572

M3 - Article

SN - 1061-4036

VL - 48

SP - 803

EP - 810

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -