A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

Buhm Han; Jennie G.  Pouget; Kamil Slowikowski; Eli Stahl; Cue Hyunkyu Lee; Dorothée Diogo; Xinli Hu; Yu Rang Park; Eunji Kim; Peter K Gregersen; Solbritt Rantapää Dahlqvist; Jane Worthington; Javier Martin; Stephen Eyre; Lars Klareskog; Tom Huizinga; Wei-Min Chen; Suna Onengut-Gumuscu; Stephen S Rich; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Naomi R Wray; Soumya Raychaudhuri

doi:10.1038/ng.3572

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

Buhm Han
, Jennie G. Pouget
, Kamil Slowikowski
, Eli Stahl
, Cue Hyunkyu Lee
, Dorothée Diogo
, Xinli Hu
, Yu Rang Park
, Eunji Kim
, Peter K Gregersen
, Solbritt Rantapää Dahlqvist
, Jane Worthington
, Javier Martin
, Stephen Eyre
, Lars Klareskog
, Tom Huizinga
, Wei-Min Chen
, Suna Onengut-Gumuscu
, Stephen S Rich
, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

Naomi R Wray, Soumya Raychaudhuri

Research output: Contribution to journal › Article › peer-review

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Original language	English
Pages (from-to)	803 - 810
Journal	Nature Genetics
Volume	48
Issue number	7
Early online date	16 May 2016
DOIs	https://doi.org/10.1038/ng.3572
Publication status	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/ng.3572

Nature Genetics 2016 Han-1Accepted author manuscript, 1.06 MB

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Han, B., Pouget, J. G., Slowikowski, K., Stahl, E., Lee, C. H., Diogo, D., Hu, X., Park, Y. R., Kim, E., Gregersen, P. K., Dahlqvist, S. R., Worthington, J., Martin, J., Eyre, S., Klareskog, L., Huizinga, T., Chen, W.-M., Onengut-Gumuscu, S., Rich, S. S., ... Raychaudhuri, S. (2016). A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nature Genetics, 48(7), 803 - 810. https://doi.org/10.1038/ng.3572

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title = "A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases",

author = "Buhm Han and Pouget, \{Jennie G.\} and Kamil Slowikowski and Eli Stahl and Lee, \{Cue Hyunkyu\} and Doroth{\'e}e Diogo and Xinli Hu and Park, \{Yu Rang\} and Eunji Kim and Gregersen, \{Peter K\} and Dahlqvist, \{Solbritt Rantap{\"a}{\"a}\} and Jane Worthington and Javier Martin and Stephen Eyre and Lars Klareskog and Tom Huizinga and Wei-Min Chen and Suna Onengut-Gumuscu and Rich, \{Stephen S\} and \{Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium\} and Wray, \{Naomi R\} and Soumya Raychaudhuri",

year = "2016",

doi = "10.1038/ng.3572",

language = "English",

volume = "48",

pages = "803 -- 810",

journal = "Nature Genetics",

issn = "1061-4036",

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}

Han, B, Pouget, JG, Slowikowski, K, Stahl, E, Lee, CH, Diogo, D, Hu, X, Park, YR, Kim, E, Gregersen, PK, Dahlqvist, SR, Worthington, J, Martin, J, Eyre, S, Klareskog, L, Huizinga, T, Chen, W-M, Onengut-Gumuscu, S, Rich, SS, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, NR & Raychaudhuri, S 2016, 'A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases', Nature Genetics, vol. 48, no. 7, pp. 803 - 810. https://doi.org/10.1038/ng.3572

TY - JOUR

T1 - A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

AU - Han, Buhm

AU - Pouget, Jennie G.

AU - Slowikowski, Kamil

AU - Stahl, Eli

AU - Lee, Cue Hyunkyu

AU - Diogo, Dorothée

AU - Hu, Xinli

AU - Park, Yu Rang

AU - Kim, Eunji

AU - Gregersen, Peter K

AU - Dahlqvist, Solbritt Rantapää

AU - Worthington, Jane

AU - Martin, Javier

AU - Eyre, Stephen

AU - Klareskog, Lars

AU - Huizinga, Tom

AU - Chen, Wei-Min

AU - Onengut-Gumuscu, Suna

AU - Rich, Stephen S

AU - Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

AU - Wray, Naomi R

AU - Raychaudhuri, Soumya

PY - 2016

Y1 - 2016

UR - https://www.scopus.com/pages/publications/84968627067

U2 - 10.1038/ng.3572

DO - 10.1038/ng.3572

M3 - Article

SN - 1061-4036

VL - 48

SP - 803

EP - 810

JO - Nature Genetics

JF - Nature Genetics

IS - 7

ER -

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

UN SDGs

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