A multifunctional light switch: DNA binding and cleavage properties of a heterobimetallic ruthenium-rhenium dipyridophenazine complex

Simon P. Foxon, Tim Phillips, Martin R. Gill, Michael Towrie, Anthony W. Parker, Michelle Webb, Jim A. Thomas

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A DNA Swiss-army knife: Photo- and biophysical studies on the hetero-dinuclear complex [{Ru(tpm)(dppz)}(μ-dpp[5]){fac-(CO) 3Re(dppz)}]3+ (see structure; tpm = tris(1-pyrazolyl) methane; dppz = dipyrido[3,2-a:2′,3′-c]phenazine; dpp[5] = 4,4′-dipyridylpentane) reveal that it is both a DNA light switch and a direct cleaving agent. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)3686-3688
    Number of pages2
    JournalAngewandte Chemie - International Edition
    Volume46
    Issue number20
    DOIs
    Publication statusPublished - 2007

    Keywords

    • DNA
    • DNA cleavage
    • Photochemistry
    • Rhenium
    • Ruthenium

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