A neural network critical for spelling

Lauren Cloutman, Leila Gingis, Melissa Newhart, Cameron Davis, Jennifer Heidler-Gary, Jennifer Crinion, Argye E. Hillis

    Research output: Contribution to journalArticlepeer-review


    We aimed to identify neuroanatomical regions associated with deficits to the graphemic buffer, a working memory component of the spelling system that holds the sequence of letter identities during production. We evaluated 331 patients with left hemisphere ischemic stroke with various spelling tests and magnetic resonance diffusion-weighted imaging and perfusion-weighted imaging, within 48 hours of stroke onset. A voxel-wise statistical map showed that ischemia in voxels in posterior and inferior frontal and parietal cortex, subcortical white matter underlying prefrontal cortex, lateral occipital gyrus, or caudate was associated with impairment in maintaining the sequence of letter identities while spelling. © 2009 American Neurological Association.
    Original languageEnglish
    Pages (from-to)249-253
    Number of pages4
    JournalAnnals of Neurology
    Issue number2
    Publication statusPublished - Aug 2009


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