A new family of bis-ureidic receptors for pyrophosphate optical sensing

Claudia Caltagirone, Carla Bazzicalupi, Francesco Isaia, Mark E. Light, Vito Lippolis, Riccardo Montis, Sergio Murgia, Martina Olivari, Giacomo Picci

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A new family of bis-ureidic receptors (L1-L6) has been synthesised. The binding properties of L1-L6 towards different anions (acetate, benzoate, glutarate, malonate, dihydrogen phosphate, hydrogen pyrophosphate, triphosphate, AMP and ADP) have been studied by means of 1H-NMR, UV-Vis and fluorescence spectroscopies and a remarkable affinity for HPpi3- has been observed in the case L3 (in DMSO-d6 and DMSO-d6-5% H2O) which also acts as a fluorimetric chemosensor, even to the naked eye, for this anion. Theoretical calculations helped us explain the binding properties observed.

    Original languageEnglish
    Pages (from-to)2445-2451
    Number of pages7
    JournalOrganic and Biomolecular Chemistry
    Volume11
    Issue number15
    DOIs
    Publication statusPublished - 16 Jan 2013

    Keywords

    • Binding properties
    • Chemosensor
    • Dihydrogen phosphate
    • Fluorimetric
    • Optical sensing
    • Synthesised
    • Theoretical calculations
    • Triphosphate
    • Fluorescence spectroscopy
    • Negative ions
    • Binding energy
    • diphosphoric acid
    • pyrophosphoric acid derivative
    • urea
    • article
    • chemical analysis
    • chemical structure
    • chemistry
    • conformation
    • equipment
    • light related phenomena
    • Chemistry Techniques, Analytical
    • Diphosphates
    • Models, Molecular
    • Molecular Conformation
    • Optical Processes

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