A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

Eduardo Guimarães Vieira; Rodrigo Boni Fazzi; Daniel O.T.A. Martins; Alena M. Sheveleva; Floriana Tuna; Ana Maria da Costa Ferreira

doi:10.1039/d2ra07266a

A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

Eduardo Guimarães Vieira, Rodrigo Boni Fazzi, Daniel O.T.A. Martins, Alena M. Sheveleva, Floriana Tuna^*, Ana Maria da Costa Ferreira^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials.

Original language	English
Pages (from-to)	9715-9719
Journal	RSC Advances
Volume	13
Issue number	14
DOIs	https://doi.org/10.1039/d2ra07266a
Publication status	Published - 24 Mar 2023

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10.1039/d2ra07266a

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title = "A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy",

abstract = "A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials.",

author = "Vieira, {Eduardo Guimar{\~a}es} and Fazzi, {Rodrigo Boni} and Martins, {Daniel O.T.A.} and Sheveleva, {Alena M.} and Floriana Tuna and {da Costa Ferreira}, {Ana Maria}",

note = "Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

year = "2023",

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doi = "10.1039/d2ra07266a",

language = "English",

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T1 - A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

AU - Vieira, Eduardo Guimarães

AU - Fazzi, Rodrigo Boni

AU - Martins, Daniel O.T.A.

AU - Sheveleva, Alena M.

AU - Tuna, Floriana

AU - da Costa Ferreira, Ana Maria

PY - 2023/3/24

Y1 - 2023/3/24

N2 - A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials.

AB - A novel strategy of improving cytotoxicity against metastatic melanoma cells using an oxindolimine copper(ii) complex immobilized and dimerized on a modified Polyhedral Oligomeric Silsesquioxane (POSS) matrix was developed, as revealed by electron paramagnetic resonance (EPR) spectroscopy. An assured correlation between continuous-wave (CW) and pulsed EPR spectroscopies provided a complete characterization of the actual active species, its coordination environment, as well as the efficiency/selectivity of the bioconjugate materials.

UR - http://www.scopus.com/inward/record.url?scp=85152148777&partnerID=8YFLogxK

U2 - 10.1039/d2ra07266a

DO - 10.1039/d2ra07266a

M3 - Article

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SN - 2046-2069

VL - 13

SP - 9715

EP - 9719

JO - RSC Advances

JF - RSC Advances

IS - 14

ER -

A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

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A new strategy for improving cytotoxicity of a copper complex toward metastatic melanoma cells unveiled by EPR spectroscopy

Abstract

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EPSRC National Research Facility for Electron Paramagnetic Resonance

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