Abstract
We have partially sequenced the light chain variable regions expressed in three IgM-producing hybridomas generated from newborn mice or from manipulated animals suppressed for IgM production. In these lines a new V gene (V-lambda-X), exhibiting less than 60% homology to any known lambda or kappa V gene, is rearranged to J-lambda-2. The light chains produced by these cells contain the lambda-2 constant domain, but are not recognized by goat antisera raised against conventional mouse lambda light chains.
| Original language | English |
|---|---|
| Pages (from-to) | 731-734 |
| Number of pages | 3 |
| Journal | European journal of immunology |
| Volume | 17 |
| Issue number | 5 |
| Publication status | Published - 1987 |