A new V gene expressed in lambda-2 light chains of the mouse

R. Dildrop; A. Gause; W. Muller; K. Rajewsky

A new V gene expressed in lambda-2 light chains of the mouse

R. Dildrop
, A. Gause
, W. Muller
, K. Rajewsky

Research output: Contribution to journal › Article › peer-review

Abstract

We have partially sequenced the light chain variable regions expressed in three IgM-producing hybridomas generated from newborn mice or from manipulated animals suppressed for IgM production. In these lines a new V gene (V-lambda-X), exhibiting less than 60% homology to any known lambda or kappa V gene, is rearranged to J-lambda-2. The light chains produced by these cells contain the lambda-2 constant domain, but are not recognized by goat antisera raised against conventional mouse lambda light chains.

Original language	English
Pages (from-to)	731-734
Number of pages	3
Journal	European journal of immunology
Volume	17
Issue number	5
Publication status	Published - 1987

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title = "A new V gene expressed in lambda-2 light chains of the mouse",

abstract = "We have partially sequenced the light chain variable regions expressed in three IgM-producing hybridomas generated from newborn mice or from manipulated animals suppressed for IgM production. In these lines a new V gene (V-lambda-X), exhibiting less than 60\% homology to any known lambda or kappa V gene, is rearranged to J-lambda-2. The light chains produced by these cells contain the lambda-2 constant domain, but are not recognized by goat antisera raised against conventional mouse lambda light chains.",

author = "R. Dildrop and A. Gause and W. Muller and K. Rajewsky",

year = "1987",

language = "English",

volume = "17",

pages = "731--734",

journal = "European journal of immunology",

issn = "1521-4141",

publisher = "John Wiley \& Sons Ltd",

number = "5",

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TY - JOUR

T1 - A new V gene expressed in lambda-2 light chains of the mouse

AU - Dildrop, R.

AU - Gause, A.

AU - Muller, W.

AU - Rajewsky, K.

PY - 1987

Y1 - 1987

N2 - We have partially sequenced the light chain variable regions expressed in three IgM-producing hybridomas generated from newborn mice or from manipulated animals suppressed for IgM production. In these lines a new V gene (V-lambda-X), exhibiting less than 60% homology to any known lambda or kappa V gene, is rearranged to J-lambda-2. The light chains produced by these cells contain the lambda-2 constant domain, but are not recognized by goat antisera raised against conventional mouse lambda light chains.

AB - We have partially sequenced the light chain variable regions expressed in three IgM-producing hybridomas generated from newborn mice or from manipulated animals suppressed for IgM production. In these lines a new V gene (V-lambda-X), exhibiting less than 60% homology to any known lambda or kappa V gene, is rearranged to J-lambda-2. The light chains produced by these cells contain the lambda-2 constant domain, but are not recognized by goat antisera raised against conventional mouse lambda light chains.

M3 - Article

C2 - 3034625

SN - 1521-4141

VL - 17

SP - 731

EP - 734

JO - European journal of immunology

JF - European journal of immunology

IS - 5

ER -

A new V gene expressed in lambda-2 light chains of the mouse

Abstract

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