A novel cofactor for p300 that regulates the p53 response

Noriko Shikama, Chang Woo Lee, Stephen France, Laurent Delavaine, Jonathan Lyon, Marija Krstic-Demonacos, Nicholas B. La Thangue

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The ability of p53 to function as a transcription factor is instrumental in facilitating the response to cellular stress, and p300/CBP proteins, which act as coactivators for diverse transcription factors, participate in regulating p53 activity. We report a novel cofactor for p300 that facilitates the p53 response by augmenting p53-dependent transcription and apoptosis. JMY and p300 associate in physiological conditions, and, during the cellular stress response, the p300/JMY complex is recruited to activated p53. The bax gene is efficiently activated by JMY, and protein isoforms that arise through alternative splicing alter the functional outcome of the p53 response. The results provide compelling evidence that the p300/JMY coactivator complex plays a central role in facilitating the p53 response.
    Original languageEnglish
    Pages (from-to)365-376
    Number of pages11
    JournalMolecular Cell
    Volume4
    Issue number3
    DOIs
    Publication statusPublished - Sept 1999

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