A novel convenient route to the naturally occurring 3-oxoacyl-L-homoserinelactones and related bacterial autoinducers

Mouloud Dekhane, Kenneth T. Douglas, Peter Gilbert

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The naturally occurring 3-oxohexanoyl-L-homoserinelactone (1a), a bacterial autoinducer has been prepared in 47% overall yield by condensing stable 3-oxohexanoic acid (2), prepared by hydrolysis from the corresponding ester (3), with L-homoserinelactone using hydroxybenzotriazole (HOBT) and dicyclohexylcarbodiimide (DCC) in non-aqueous media.
    Original languageEnglish
    Pages (from-to)1883-1884
    Number of pages1
    JournalTetrahedron Letters
    Volume37
    Issue number11
    DOIs
    Publication statusPublished - 11 Mar 1996

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