A novel ex vivo model of compressive immature rib fractures at pathophysiological rates of loading

N Beadle; Timothy Burnett; JA Hoyland; Michael Sherratt; Anthony J Freemont

doi:10.1016/j.jmbbm.2015.06.031

A novel ex vivo model of compressive immature rib fractures at pathophysiological rates of loading

N Beadle, Timothy Burnett, JA Hoyland, Michael Sherratt, Anthony J Freemont

Division of Cell Matrix Biology & Regenerative Medicine (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Compressive rib fractures are considered to be indicative of non-accidental injury (NAI) in infants, which is a significant and growing issue worldwide. The diagnosis of NAI is often disputed in a legal setting, and as a consequence there is a need to model such injuries ex vivo in order to characterise the forces required to produce non-accidental rib fractures. However, current models are limited by type of sample, loading method and rate of loading. Here, we aimed to: i) develop a loading system for inducing compressive fractures in whole immature ribs that is more representative of the physiological conditions and mechanism of injury employed in NAI and ii) assess the influence of loading rate and rib geometry on the mechanical performance of the tissue.

Original language	English
Pages (from-to)	154-162
Number of pages	8
Journal	Journal of the mechanical behavior of biomedical materials
Volume	51
DOIs	https://doi.org/10.1016/j.jmbbm.2015.06.031
Publication status	Published - Nov 2015

Keywords

Rib fracture
Non-accidental injury
Forensic biomechanics
Loading rate
Axial compression

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10.1016/j.jmbbm.2015.06.031

http://www.sciencedirect.com/science/article/pii/S1751616115002362

Structural Evolution across multiple time and length scales
Withers, P. (PI), Cartmell, S. (CoI), Cernik, R. (CoI), Derby, B. (CoI), Eichhorn, S. (CoI), Freemont, A. (CoI), Hollis, C. (CoI), Mummery, P. (CoI), Sherratt, M. (CoI), Thompson, G. (CoI) & Watts, D. (CoI)
1/06/11 → 31/05/16
Project: Research

Cite this

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title = "A novel ex vivo model of compressive immature rib fractures at pathophysiological rates of loading",

abstract = "Compressive rib fractures are considered to be indicative of non-accidental injury (NAI) in infants, which is a significant and growing issue worldwide. The diagnosis of NAI is often disputed in a legal setting, and as a consequence there is a need to model such injuries ex vivo in order to characterise the forces required to produce non-accidental rib fractures. However, current models are limited by type of sample, loading method and rate of loading. Here, we aimed to: i) develop a loading system for inducing compressive fractures in whole immature ribs that is more representative of the physiological conditions and mechanism of injury employed in NAI and ii) assess the influence of loading rate and rib geometry on the mechanical performance of the tissue.",

keywords = "Rib fracture, Non-accidental injury, Forensic biomechanics, Loading rate, Axial compression",

author = "N Beadle and Timothy Burnett and JA Hoyland and Michael Sherratt and Freemont, {Anthony J}",

note = "The authors would like to thank Norman Henry (Biological Services Facility, University of Manchester) for supplying the animals used in the study and Andy Fotheringham for advice regarding the loading apparatus. The work in this study was funded by the Engineering and Physical Sciences Research Council (EPSRC) (EP/I02249X/1).",

year = "2015",

month = nov,

doi = "10.1016/j.jmbbm.2015.06.031",

language = "English",

volume = "51",

pages = "154--162",

journal = "Journal of the mechanical behavior of biomedical materials",

issn = "1751-6161",

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AU - Beadle, N

AU - Burnett, Timothy

AU - Hoyland, JA

AU - Sherratt, Michael

AU - Freemont, Anthony J

N1 - The authors would like to thank Norman Henry (Biological Services Facility, University of Manchester) for supplying the animals used in the study and Andy Fotheringham for advice regarding the loading apparatus. The work in this study was funded by the Engineering and Physical Sciences Research Council (EPSRC) (EP/I02249X/1).

PY - 2015/11

Y1 - 2015/11

N2 - Compressive rib fractures are considered to be indicative of non-accidental injury (NAI) in infants, which is a significant and growing issue worldwide. The diagnosis of NAI is often disputed in a legal setting, and as a consequence there is a need to model such injuries ex vivo in order to characterise the forces required to produce non-accidental rib fractures. However, current models are limited by type of sample, loading method and rate of loading. Here, we aimed to: i) develop a loading system for inducing compressive fractures in whole immature ribs that is more representative of the physiological conditions and mechanism of injury employed in NAI and ii) assess the influence of loading rate and rib geometry on the mechanical performance of the tissue.

AB - Compressive rib fractures are considered to be indicative of non-accidental injury (NAI) in infants, which is a significant and growing issue worldwide. The diagnosis of NAI is often disputed in a legal setting, and as a consequence there is a need to model such injuries ex vivo in order to characterise the forces required to produce non-accidental rib fractures. However, current models are limited by type of sample, loading method and rate of loading. Here, we aimed to: i) develop a loading system for inducing compressive fractures in whole immature ribs that is more representative of the physiological conditions and mechanism of injury employed in NAI and ii) assess the influence of loading rate and rib geometry on the mechanical performance of the tissue.

KW - Rib fracture

KW - Non-accidental injury

KW - Forensic biomechanics

KW - Loading rate

KW - Axial compression

U2 - 10.1016/j.jmbbm.2015.06.031

DO - 10.1016/j.jmbbm.2015.06.031

M3 - Article

C2 - 26253206

SN - 1751-6161

VL - 51

SP - 154

EP - 162

JO - Journal of the mechanical behavior of biomedical materials

JF - Journal of the mechanical behavior of biomedical materials

ER -

A novel ex vivo model of compressive immature rib fractures at pathophysiological rates of loading

Abstract

Keywords

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Projects

Structural Evolution across multiple time and length scales

Cite this