A Novel Methodology for Economical Scale-Up of TiO 2 Nanotubes Fabricated on Ti and Ti Alloys

Juan Shong Khaw, Michele Curioni, Peter Skeldon, Christopher R. Bowen, Sarah H. Cartmell

Research output: Contribution to journalArticlepeer-review


The prospective use of nanotechnology for medical devices is increasing. While the impact of material surface nanopatterning on the biological response is convincing, creating a large surface area with such nanotechnology remains an unmet challenge. In this paper, we describe, for the first time, a reproducible scale-up manufacturing technique for creating controlled nanotubes on the surfaces of Ti and Ti alloys. We describe an average of approximately 7.5-fold increase in cost and time efficiency with regards to the generation of 20, 50, and 100 nm diameter nanotubes using an anodisation technique. These novel materials have great potential in the medical field through their influence on cellular activity, in particular, protein absorption, focal adhesion, and osteoinduction. In this paper, we provide a step-by-step guide to optimise an anodisation system, starting with design rationale, proof of concept, device upscaling, consistency, and reproducibility check, followed by cost and efficiency analysis. We show that the optimised device can produce a high number of anodised specimens with customisable specimen shape at reduced cost and time, without compromising the repeatability and consistency. The device can fabricate highly uniform and vertically oriented TiO 2 nanotube layer with desired pore diameters.

Original languageEnglish
Article number5902346
JournalJournal of Nanotechnology
Early online date3 Mar 2019
Publication statusPublished - 2019

Research Beacons, Institutes and Platforms

  • Dalton Nuclear Institute


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