A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo

Marta Bertolini, J. Chéret, D. Pinto, Nathan Hawkshaw, L. Ponce, Ralf Paus, H. Erdmann, F. Jimenez, W. Funk

Research output: Contribution to specialist publicationLetter

Abstract

Wnt signalling is one of the most fundamental molecular pathways for modulating the human hair cycle and is essential for maintaining hair growth1. We recently identified that the Wnt antagonist, secreted frizzled related protein 1 (SFRP1), prematurely induces catagen in microdissected human scalp hair follicles (HFs) ex vivo1. SFRP1 is inhibited by the potent hypertrichosis inducing immunosuppressant, cyclosporine A (CsA)2, and the specific SFRP1 antagonist, WAY‐316606, both of which prevent spontaneous catagen development1.
Original languageEnglish
Specialist publicationBritish Journal of Dermatology
DOIs
Publication statusPublished - 16 Sep 2020

Fingerprint

Dive into the research topics of 'A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo'. Together they form a unique fingerprint.

Cite this