A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo

Marta Bertolini; J. Chéret; D. Pinto; Nathan Hawkshaw; L. Ponce; Ralf Paus; H. Erdmann; F. Jimenez; W. Funk

doi:10.1111/bjd.19552

A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo

Marta Bertolini, J. Chéret, D. Pinto, Nathan Hawkshaw, L. Ponce, Ralf Paus, H. Erdmann, F. Jimenez, W. Funk

Division of Musculoskeletal & Dermatological Sciences (L5)

Research output: Contribution to specialist publication › Letter

Abstract

Wnt signalling is one of the most fundamental molecular pathways for modulating the human hair cycle and is essential for maintaining hair growth1. We recently identified that the Wnt antagonist, secreted frizzled related protein 1 (SFRP1), prematurely induces catagen in microdissected human scalp hair follicles (HFs) ex vivo1. SFRP1 is inhibited by the potent hypertrichosis inducing immunosuppressant, cyclosporine A (CsA)2, and the specific SFRP1 antagonist, WAY‐316606, both of which prevent spontaneous catagen development1.

Original language	English
Specialist publication	British Journal of Dermatology
DOIs	https://doi.org/10.1111/bjd.19552
Publication status	Published - 16 Sept 2020

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10.1111/bjd.19552

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title = "A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo",

abstract = "Wnt signalling is one of the most fundamental molecular pathways for modulating the human hair cycle and is essential for maintaining hair growth1. We recently identified that the Wnt antagonist, secreted frizzled related protein 1 (SFRP1), prematurely induces catagen in microdissected human scalp hair follicles (HFs) ex vivo1. SFRP1 is inhibited by the potent hypertrichosis inducing immunosuppressant, cyclosporine A (CsA)2, and the specific SFRP1 antagonist, WAY‐316606, both of which prevent spontaneous catagen development1.",

author = "Marta Bertolini and J. Ch{\'e}ret and D. Pinto and Nathan Hawkshaw and L. Ponce and Ralf Paus and H. Erdmann and F. Jimenez and W. Funk",

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T1 - A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo

AU - Bertolini, Marta

AU - Chéret, J.

AU - Pinto, D.

AU - Hawkshaw, Nathan

AU - Ponce, L.

AU - Paus, Ralf

AU - Erdmann, H.

AU - Jimenez, F.

AU - Funk, W.

PY - 2020/9/16

Y1 - 2020/9/16

N2 - Wnt signalling is one of the most fundamental molecular pathways for modulating the human hair cycle and is essential for maintaining hair growth1. We recently identified that the Wnt antagonist, secreted frizzled related protein 1 (SFRP1), prematurely induces catagen in microdissected human scalp hair follicles (HFs) ex vivo1. SFRP1 is inhibited by the potent hypertrichosis inducing immunosuppressant, cyclosporine A (CsA)2, and the specific SFRP1 antagonist, WAY‐316606, both of which prevent spontaneous catagen development1.

AB - Wnt signalling is one of the most fundamental molecular pathways for modulating the human hair cycle and is essential for maintaining hair growth1. We recently identified that the Wnt antagonist, secreted frizzled related protein 1 (SFRP1), prematurely induces catagen in microdissected human scalp hair follicles (HFs) ex vivo1. SFRP1 is inhibited by the potent hypertrichosis inducing immunosuppressant, cyclosporine A (CsA)2, and the specific SFRP1 antagonist, WAY‐316606, both of which prevent spontaneous catagen development1.

U2 - 10.1111/bjd.19552

DO - 10.1111/bjd.19552

M3 - Letter

SN - 0007-0963

JO - British Journal of Dermatology

JF - British Journal of Dermatology

ER -

A novel non‐drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo

Abstract

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