A novel optical biosensor with internal referencing

R Gupta, N J Goddard

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    This work reports a novel sensor with internal referencing to eliminate the undesirable effects of variations in background refractive index and non-specific interactions. The sensor is based on a two layer metal-clad leaky waveguide that supports two optical modes that are largely confined to one or other of the two waveguide layers. The lower or buried waveguide layer is used as a ref. to remove common-mode effects such as refractive index changes arising from temp. or compositional changes. The upper waveguide layer is activated by covalent immobilization of an antibody. It has been shown exptl. that this method reduces the sensitivity to bulk refractive index change by a factor of 30.5 and the sensitivity to temp. by a factor of 18.0 compared to an unreferenced sensor. [on SciFinder(R)]
    Original languageEnglish
    Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences 27-31 October 2013, Freiburg, Germany
    PublisherCurran Associates Incorporated
    Number of pages3
    Publication statusPublished - 2014

    Publication series

    NameInt. Conf. Miniaturized Syst. Chem. Life Sci., 17th


    • Optical sensors (biosensors
    • study on novel optical biosensor with internal referencing)
    • Biosensors (optical
    • Physiological saline solutions (phosphate-buffered
    • Albumins (serum, bovine
    • Immunoglobulin G
    • Optical reflection
    • Refractive index
    • Temperature effects (study on novel optical biosensor with internal referencing)
    • optical biosensor internal referencing


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