A novel phosphonate for the repair of critical size bone defects

A. K. Bassi, J. E. Gough, S. Downes

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Bone has the ability to spontaneously regenerate itself. However, the treatment of critical size bone defects can be problematic. In this study, the healing potential of critical size neonatal mouse parietal defects was evaluated using a scaffold composed of poly (ε-caprolactone) (PCL) and polyvinyl phosphonic co-acrylic acid (PVPA) (referred to as PCL/PVPA). Full thickness 1.5mm circular defects were created in parietal bones obtained from one litter of 4-day-old CD1 mice. The bones were divided into two groups and embedded with PCL or PCL/PVPA scaffolds. The healing response was evaluated using microcomputed tomography, dissecting microscopy, phase contrast microscopy, scanning electron microscopy, and energy dispersive spectroscopy. There was a significant increase (P
    Original languageEnglish
    Pages (from-to)833-840
    Number of pages7
    JournalJournal of Tissue Engineering and Regenerative Medicine
    Volume6
    Issue number10
    Early online date29 Oct 2012
    DOIs
    Publication statusPublished - Nov 2012

    Keywords

    • Biodegradable polymers
    • Bone tissue engineering
    • Critical size defects
    • Micro-CT
    • Organ culture
    • Osteoporosis

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