A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles

Gabriella Ieronimo, Giovanni Palmisano, Angelo Maspero, Alessandro Marzorati, Luca Scapinello, Norberto Masciocchi, Giancarlo Cravotto, Alessandro Barge, Marco Simonetti, Keshav Lalit Ameta, Kenneth M. Nicholas, Andrea Penoni

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A straightforward indole synthesis via annulation of C-nitrosoaromatics with conjugated terminal alkynones was realised achieving a simple, highly regioselective, atom- and step economical access to 3-aroylindoles in moderate to good yields. Further functionalizations of indole scaffolds were investigated and an easy way to JWH-018, a synthetic cannabinoid, was achieved.
    Original languageEnglish
    Pages (from-to)6853-6859
    Number of pages6
    JournalOrganic & biomolecular chemistry
    Volume16
    Issue number38
    Early online date24 Jul 2018
    DOIs
    Publication statusPublished - 2018

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