A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors

Atish D. Choudhury; Celestia S. Higano; Johann S. de Bono; Natalie Cook; Dana E. Rathkopf; Kari B. Wisinski; Juan Martin-Liberal; Mark Linch; Elisabeth I. Heath; Richard D. Baird; Javier García-Carbacho; Miguel Quintela-Fandino; Simon T. Barry; Elza C. de Bruin; Steve Colebrook; George Hawkins; Teresa Klinowska; Brijesh Maroj; Ganesh Moorthy; Peter G. Mortimer; Michele Moschetta; Myria Nikolaou; Liz Sainsbury; Geoffrey I. Shapiro; Lillian L. Siu; Aaron R. Hansen

doi:10.1158/1078-0432.CCR-21-3087

A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors

Atish D. Choudhury
, Celestia S. Higano
, Johann S. de Bono
, Natalie Cook
, Dana E. Rathkopf
, Kari B. Wisinski
, Juan Martin-Liberal
, Mark Linch
, Elisabeth I. Heath
, Richard D. Baird
, Javier García-Carbacho
, Miguel Quintela-Fandino
, Simon T. Barry
, Elza C. de Bruin
, Steve Colebrook
, George Hawkins
, Teresa Klinowska
, Brijesh Maroj
, Ganesh Moorthy
, Peter G. Mortimer

Michele Moschetta, Myria Nikolaou, Liz Sainsbury, Geoffrey I. Shapiro, Lillian L. Siu, Aaron R. Hansen

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Original language	Undefined
Journal	Clinical Cancer Research
DOIs	https://doi.org/10.1158/1078-0432.CCR-21-3087
Publication status	Published - 1 Jun 2022

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1078-0432.CCR-21-3087

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Choudhury, A. D., Higano, C. S., Bono, J. S. D., Cook, N., Rathkopf, D. E., Wisinski, K. B., Martin-Liberal, J., Linch, M., Heath, E. I., Baird, R. D., García-Carbacho, J., Quintela-Fandino, M., Barry, S. T., Bruin, E. C. D., Colebrook, S., Hawkins, G., Klinowska, T., Maroj, B., Moorthy, G., ... Hansen, A. R. (2022). A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-3087

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title = "A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors",

author = "Choudhury, \{Atish D.\} and Higano, \{Celestia S.\} and Bono, \{Johann S. de\} and Natalie Cook and Rathkopf, \{Dana E.\} and Wisinski, \{Kari B.\} and Juan Martin-Liberal and Mark Linch and Heath, \{Elisabeth I.\} and Baird, \{Richard D.\} and Javier Garc{\'i}a-Carbacho and Miguel Quintela-Fandino and Barry, \{Simon T.\} and Bruin, \{Elza C. de\} and Steve Colebrook and George Hawkins and Teresa Klinowska and Brijesh Maroj and Ganesh Moorthy and Mortimer, \{Peter G.\} and Michele Moschetta and Myria Nikolaou and Liz Sainsbury and Shapiro, \{Geoffrey I.\} and Siu, \{Lillian L.\} and Hansen, \{Aaron R.\}",

year = "2022",

month = jun,

day = "1",

doi = "10.1158/1078-0432.CCR-21-3087",

language = "Undefined",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research",

}

Choudhury, AD, Higano, CS, Bono, JSD, Cook, N, Rathkopf, DE, Wisinski, KB, Martin-Liberal, J, Linch, M, Heath, EI, Baird, RD, García-Carbacho, J, Quintela-Fandino, M, Barry, ST, Bruin, ECD, Colebrook, S, Hawkins, G, Klinowska, T, Maroj, B, Moorthy, G, Mortimer, PG, Moschetta, M, Nikolaou, M, Sainsbury, L, Shapiro, GI, Siu, LL & Hansen, AR 2022, 'A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors', Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-3087

TY - JOUR

T1 - A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors

AU - Choudhury, Atish D.

AU - Higano, Celestia S.

AU - Bono, Johann S. de

AU - Cook, Natalie

AU - Rathkopf, Dana E.

AU - Wisinski, Kari B.

AU - Martin-Liberal, Juan

AU - Linch, Mark

AU - Heath, Elisabeth I.

AU - Baird, Richard D.

AU - García-Carbacho, Javier

AU - Quintela-Fandino, Miguel

AU - Barry, Simon T.

AU - Bruin, Elza C. de

AU - Colebrook, Steve

AU - Hawkins, George

AU - Klinowska, Teresa

AU - Maroj, Brijesh

AU - Moorthy, Ganesh

AU - Mortimer, Peter G.

AU - Moschetta, Michele

AU - Nikolaou, Myria

AU - Sainsbury, Liz

AU - Shapiro, Geoffrey I.

AU - Siu, Lillian L.

AU - Hansen, Aaron R.

PY - 2022/6/1

Y1 - 2022/6/1

UR - https://doi.org/10.1158/1078-0432.CCR-21-3087

U2 - 10.1158/1078-0432.CCR-21-3087

DO - 10.1158/1078-0432.CCR-21-3087

M3 - Article

SN - 1078-0432

JO - Clinical Cancer Research

JF - Clinical Cancer Research

ER -

A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors

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