A Pilot Interventional Study to Evaluate the Impact of Cholecalciferol Treatment on HbA1c in Type 1 Diabetes (T1D)

Reena Perchard, Linda Magee, Andrew Whatmore, F. Ivison, Philip Murray, Frederick Stevens, M Z. Mughal, S. Ehtisham, J Campbell, S Ainsworth, M Marshall, M Bone, I Doughty, Peter Clayton

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BACKGROUND: Higher 25(OH)D3 levels are associated with lower HbA1c, but there are limited UK interventional trials assessing the effect of cholecalciferol on HbA1c.

AIMS: (1) To assess the baseline 25(OH)D3 status in a Manchester cohort of children with type 1 diabetes (T1D). (2) To determine the effect of cholecalciferol administration on HbA1c.

METHODS: Children with T1D attending routine clinic appointments over three months in late winter/early spring had blood samples taken with consent. Participants with a 25(OH)D3 level <50 nmol/L were treated with a one-off cholecalciferol dose of 100,000 (2-10 years) or 160,000 (>10 years) units. HbA1c levels before and after treatment were recorded.

RESULTS: Vitamin D levels were obtained from 51 children. 35 were Caucasian, 11 South Asian and 5 from other ethnic groups. 42 were vitamin D deficient, but 2 were excluded from the analysis. All South Asian children were vitamin D deficient, with mean 25(OH)D3 of 28 nmol/L. In Caucasians, there was a negative relationship between baseline 25(OH)D3 level and HbA1c (r = -0.484, P < 0.01). In treated participants, there was no significant difference in mean HbA1c at 3 months (t = 1.010, P = 0.328) or at 1 year (t = -1.173, P = 0.248) before and after treatment. One-way ANCOVA, controlling for age, gender, ethnicity, BMI and diabetes duration showed no difference in Δ HbA1c level.

CONCLUSION: We report important findings at baseline, but in children treated with a stat dose of cholecalciferol, there was no effect on HbA1c. Further studies with larger sample sizes and using maintenance therapy are required.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalEndocrine Connections
Issue number4
Early online date4 May 2017
Publication statusPublished - May 2017


  • Diabetes
  • Bone
  • Paediatric endocrinology
  • Vitamin D
  • HbA1c


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