A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsies

Riaz Akhtar, J. Kennedy Cruickshank, Xuegen Zhao, Brian Derby, Thomas Weber

Research output: Contribution to journalArticlepeer-review

Abstract

This study explores the use of scanning acoustic microscopy (SAM) as a potential tool for characterisation of arterial stiffness using aortic biopsies. SAM data is presented for human tissue collected during aortic bypass graft surgery for multi-vessel coronary artery disease. Acoustic wave speed as determined by SAM was compared to clinical data for the patients namely, pulse wave velocity (PWV), blood pressure, cholesterol and glucose levels. There was no obvious trend relating acoustic wave speed to PWV values, and an inverse relationship was found between systolic and diastolic blood pressure and acoustic wave speed. However, in patients with a higher cholesterol or glucose level, the acoustic wave speed increased. A more detailed investigation is needed to relate SAM data to clinical measurements.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalArtery Research
Volume13
DOIs
Publication statusPublished - 1 Mar 2016

Keywords

  • Acoustic wave speed
  • Arterial stiffening
  • Blood pressure
  • Cholesterol
  • Glucose
  • Pulse wave velocity
  • Scanning acoustic microscopy

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