A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsies

Riaz Akhtar; J. Kennedy Cruickshank; Xuegen Zhao; Brian Derby; Thomas Weber

doi:10.1016/j.artres.2015.11.001

A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsies

Riaz Akhtar^*, J. Kennedy Cruickshank, Xuegen Zhao, Brian Derby, Thomas Weber

^*Corresponding author for this work

The University of Manchester

Research output: Contribution to journal › Article › peer-review

Abstract

This study explores the use of scanning acoustic microscopy (SAM) as a potential tool for characterisation of arterial stiffness using aortic biopsies. SAM data is presented for human tissue collected during aortic bypass graft surgery for multi-vessel coronary artery disease. Acoustic wave speed as determined by SAM was compared to clinical data for the patients namely, pulse wave velocity (PWV), blood pressure, cholesterol and glucose levels. There was no obvious trend relating acoustic wave speed to PWV values, and an inverse relationship was found between systolic and diastolic blood pressure and acoustic wave speed. However, in patients with a higher cholesterol or glucose level, the acoustic wave speed increased. A more detailed investigation is needed to relate SAM data to clinical measurements.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Artery Research
Volume	13
DOIs	https://doi.org/10.1016/j.artres.2015.11.001
Publication status	Published - 1 Mar 2016

Keywords

Acoustic wave speed
Arterial stiffening
Blood pressure
Cholesterol
Glucose
Pulse wave velocity
Scanning acoustic microscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.artres.2015.11.001

Cite this

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title = "A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsies",

abstract = "This study explores the use of scanning acoustic microscopy (SAM) as a potential tool for characterisation of arterial stiffness using aortic biopsies. SAM data is presented for human tissue collected during aortic bypass graft surgery for multi-vessel coronary artery disease. Acoustic wave speed as determined by SAM was compared to clinical data for the patients namely, pulse wave velocity (PWV), blood pressure, cholesterol and glucose levels. There was no obvious trend relating acoustic wave speed to PWV values, and an inverse relationship was found between systolic and diastolic blood pressure and acoustic wave speed. However, in patients with a higher cholesterol or glucose level, the acoustic wave speed increased. A more detailed investigation is needed to relate SAM data to clinical measurements.",

keywords = "Acoustic wave speed, Arterial stiffening, Blood pressure, Cholesterol, Glucose, Pulse wave velocity, Scanning acoustic microscopy",

author = "Riaz Akhtar and Cruickshank, {J. Kennedy} and Xuegen Zhao and Brian Derby and Thomas Weber",

year = "2016",

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doi = "10.1016/j.artres.2015.11.001",

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AU - Akhtar, Riaz

AU - Cruickshank, J. Kennedy

AU - Zhao, Xuegen

AU - Derby, Brian

AU - Weber, Thomas

PY - 2016/3/1

Y1 - 2016/3/1

N2 - This study explores the use of scanning acoustic microscopy (SAM) as a potential tool for characterisation of arterial stiffness using aortic biopsies. SAM data is presented for human tissue collected during aortic bypass graft surgery for multi-vessel coronary artery disease. Acoustic wave speed as determined by SAM was compared to clinical data for the patients namely, pulse wave velocity (PWV), blood pressure, cholesterol and glucose levels. There was no obvious trend relating acoustic wave speed to PWV values, and an inverse relationship was found between systolic and diastolic blood pressure and acoustic wave speed. However, in patients with a higher cholesterol or glucose level, the acoustic wave speed increased. A more detailed investigation is needed to relate SAM data to clinical measurements.

AB - This study explores the use of scanning acoustic microscopy (SAM) as a potential tool for characterisation of arterial stiffness using aortic biopsies. SAM data is presented for human tissue collected during aortic bypass graft surgery for multi-vessel coronary artery disease. Acoustic wave speed as determined by SAM was compared to clinical data for the patients namely, pulse wave velocity (PWV), blood pressure, cholesterol and glucose levels. There was no obvious trend relating acoustic wave speed to PWV values, and an inverse relationship was found between systolic and diastolic blood pressure and acoustic wave speed. However, in patients with a higher cholesterol or glucose level, the acoustic wave speed increased. A more detailed investigation is needed to relate SAM data to clinical measurements.

KW - Acoustic wave speed

KW - Arterial stiffening

KW - Blood pressure

KW - Cholesterol

KW - Glucose

KW - Pulse wave velocity

KW - Scanning acoustic microscopy

U2 - 10.1016/j.artres.2015.11.001

DO - 10.1016/j.artres.2015.11.001

M3 - Article

AN - SCOPUS:84958238897

SN - 1872-9312

VL - 13

SP - 1

EP - 5

JO - Artery Research

JF - Artery Research

ER -

A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsies

Abstract

Keywords

UN SDGs

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