@article{66bd6f3bf7e64f499b68ebec64527935,
title = "A platform for experimental precision medicine: The extended BXD mouse family",
abstract = "The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely powerful model for precision medicine. This family segregates for 6 million common DNA variants—a level that exceeds many human populations. Because each member can be replicated, heritable traits can be mapped with high power and precision. Current BXD phenomes are unsurpassed in coverage and include much omics data and thousands of quantitative traits. BXDs can be extended by a single-generation cross to as many as 19,460 isogenic F1 progeny, and this extended BXD family is an effective platform for testing causal modeling and for predictive validation. BXDs are a unique core resource for the field of experimental precision medicine.",
keywords = "GXE, complex trait, gene mapping, personalized medicine, power calculation, recombinant inbred strains, systems biology, systems genetics",
author = "David Ashbrook and Danny Arends and P Prins and Megan Mulligan and S Roy and Williams, {Evan G} and CM Lutz and Abel Valenzuela and CG Bohl and JS Ingels and MS McCarty and AG Centena and Reinmar Hager and Johan Auwerx and L Lu and Williams, {Robert W.}",
note = "Funding Information: Thanks to Dr. Abraham Palmer for providing B6D2 AI progeny (G8 and G9) to make BXD160 through BXD186. We thank Drs. Gerald McClearn and Lisa Tarantino for 60 eighth-generation (G8) AI progeny from Pennsylvania State University that contributed to epoch 3. We thank Dr. Benjamin A. Taylor for initiating the BXD and for continued support and encouragement. We thank Dr. Saunak Sen for consultation on power calculations and qtlDesign. We thank members of the EPFL Center for Phenogenomics, in particular, Drs. Xavier Warot and Emilie Gesina for sharing data from their BXD colony, and Erik Soehnel from Scionics for assistance in obtaining the full breeding statistics. The UTHSC Center for Integrative and Translational Genomics (CITG) has supported production of the BXD colony at UTHSC and will continue to support this colony for the duration of the grant. The CITG also provides generous support for computer hardware and programming associated with GeneNetwork, and our Galaxy and UCSC Genome Browser instances. We thank the support of the UT Center for Integrative and Translational Genomics and funds from the UT-ORNL Governor's Chair, NIDA grant P30DA044223 and NIAAA U01 AA013499, U01 AA016662, and U01 AA014425 for the work at UTHSC. Work in the Auwerx lab on the BXDs is supported by the ?cole Polytechnique F?d?rale de Lausanne, the ERC (AdG-787702), the SNSF (310030B-160318), the AgingX program of the Swiss Initiative for Systems Biology (RTD 2013/153), and the NIH (R01AG043930). The BXD Resource at the Jackson Laboratory is supported by NIH P40 OD011102 awarded to Dr. Cathleen M. Lutz. The data sets generated and/or analyzed during the current study are available in the GeneNetwork repository, https://www.genenetwork.org/. Conceptualization, R.W.W. L.L. and J.A.; Methodology, D.G.A. D.A. P.P. J.A. L.L. and R.W.W.; Software D.G.A. D.A. P.P. A.G.C. L.L. and R.W.W.; Formal Analysis, D.G.A. D.A. E.G.W. R.H. and S.S.; Investigation; S.R. C.M.L. A.V. C.J.B. J.F.I. and M.S.M.; Resources, C.M.L. and A.V.; Data Curation, D.G.A. D.A. and A.G.C. and R.W.W.; Writing ? Original Draft, D.G.A. D.A. R.H. and R.W.W.; Writing ? Review & Editing, D.G.A. D.A. P.P. M.K.M. S.R. E.G.W. R.H. J.H. L.L. and R.W.W.; Visualization, D.G.A. D.A. and E.G.W.; Supervision, J.A. L.L. and R.W.W.; Funding Acquisition, R.W.W. J.A. and C.M.L. The authors declare no competing interests. Funding Information: We thank the support of the UT Center for Integrative and Translational Genomics and funds from the UT-ORNL Governor's Chair, NIDA grant P30DA044223 and NIAAA U01 AA013499 , U01 AA016662 , and U01 AA014425 for the work at UTHSC. Work in the Auwerx lab on the BXDs is supported by the {\'E}cole Polytechnique F{\'e}d{\'e}rale de Lausanne , the ERC ( AdG-787702 ), the SNSF ( 310030B-160318 ), the AgingX program of the Swiss Initiative for Systems Biology ( RTD 2013/153 ), and the NIH ( R01AG043930 ). The BXD Resource at the Jackson Laboratory is supported by NIH P40 OD011102 awarded to Dr. Cathleen M. Lutz. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = mar,
day = "17",
doi = "10.1016/j.cels.2020.12.002",
language = "English",
volume = "12",
pages = "235--247.e9",
journal = "Cell Systems",
issn = "2405-4712",
publisher = "Cell Press",
number = "3",
}